Pricing updated 2019-06-15. Prices are subject to change without notice.
(±)-Baclofen is a GABAB receptor agonist (IC50 = 180 nM).1 It induces norepinephrine release from isolated rat atria (IC50 = 4.5 μM). (±)-Baclofen (10 mg/kg) increases muscle rigidity in spastic mice.2 It inhibits the norepinephrine-induced group II flexor reflex in anesthetized rats.3 (±)-Baclofen also reduces cocaine-induced hyperlocomotion in rats and binge-like ethanol intake in mice.4,5 Formulations containing baclofen have been used to treat muscle spasms caused by multiple sclerosis and spinal cord injury.
Warning - this product is not for human or veterinary use.
View the Cayman Structure Database for chemical structure definitions for many Cayman products
Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.
Hill, D.R., and Bowery, N.G. 3H-
2. Biscoe, T.J., and Fry, J.P. Some pharmacological studies on the spastic mouse Br. J. Pharmacol. 75(1), 23-25 (1982).
Sakitani, K. The effects of centrally acting muscle relaxants on the intrathecal noradrenaline-
Lhuillier, L., Mombereau, C., Cryan, J.F., et al. GABAB receptor-
Moore, E.M., and Boehm, S.L., II Site-