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(±)-Baclofen

Item № 18600
CAS № 1134-47-0
Purity ≥98%
product image
                (CAS 1134-47-0)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 g $35.00 0.00
     5 g $105.00 0.00
     10 g $193.00 0.00
     25 g $315.00 0.00

Pricing updated 2019-06-15. Prices are subject to change without notice.

Description

(±)-Baclofen is a GABAB receptor agonist (IC50 = 180 nM).1 It induces norepinephrine release from isolated rat atria (IC50 = 4.5 μM). (±)-Baclofen (10 mg/kg) increases muscle rigidity in spastic mice.2 It inhibits the norepinephrine-induced group II flexor reflex in anesthetized rats.3 (±)-Baclofen also reduces cocaine-induced hyperlocomotion in rats and binge-like ethanol intake in mice.4,5 Formulations containing baclofen have been used to treat muscle spasms caused by multiple sclerosis and spinal cord injury.

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Technical Information
Formal Name
β-(aminomethyl)-4-chloro-benzenepropanoic acid
CAS Number
1134-47-0
Molecular Formula
C10H12ClNO2
Formula Weight
213.7
Purity
≥98%
Formulation
A crystalline solid
λmax
220, 266 nm
SMILES
ClC1=CC=C(C(CN)CC(O)=O)C=C1
InChI Code
InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
InChI Key
KPYSYYIEGFHWSV-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Hill, D.R., and Bowery, N.G. 3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brain Nature 290(5802), (1981).

2. Biscoe, T.J., and Fry, J.P. Some pharmacological studies on the spastic mouse Br. J. Pharmacol. 75(1), 23-25 (1982).

3. Sakitani, K. The effects of centrally acting muscle relaxants on the intrathecal noradrenaline-induced facilitation of the flexor reflex mediated by group II afferent fibers in rats Jpn. J. Pharmacol. 63(3), 369-376 (1993).

4. Lhuillier, L., Mombereau, C., Cryan, J.F., et al. GABAB receptor-positive modulation decreases selective molecular and behavioral effects of cocaine Neuropsychopharmacology 32(2), 388-398 (2007).

5. Moore, E.M., and Boehm, S.L., II Site-specific microinjection of baclofen into the anterior ventral tegmental area reduces binge-like ethanol intake in male C57BL/6J mice Behav. Neurosci. 123(3), 555-563 (2009).

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