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(±)-Baclofen

Item № 18600
CAS № 1134-47-0
Purity ≥98%
product image
                (CAS 1134-47-0)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 g $35.00 0.00
     5 g $105.00 0.00
     10 g $193.00 0.00
     25 g $315.00 0.00

Pricing updated 2019-03-24. Prices are subject to change without notice.

Description

γ-Aminobutyric acid (GABA) is an inhibitory neurotransmitter that acts through heteromeric ligand-gated ion channels, GABAA and GABAC, and a G protein-coupled receptor, GABAB. (±)-Baclofen is a selective agonist of GABAB (IC50 = 200 nM).1 By activating GABAB, (±)-baclofen causes skeletal muscle relaxation and blocks spasticity.2,3,4 It also modifies animal responses to alcohol and cocaine.5,6

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Technical Information
Formal Name
β-(aminomethyl)-4-chloro-benzenepropanoic acid
CAS Number
1134-47-0
Molecular Formula
C10H12ClNO2
Formula Weight
213.7
Purity
≥98%
Formulation
A crystalline solid
λmax
220, 266 nm
SMILES
ClC1=CC=C(C(CN)CC(O)=O)C=C1
InChI Code
InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
InChI Key
KPYSYYIEGFHWSV-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Berthelot, P., Vaccher, C., Musadad, A., et al. Synthesis and pharmacological evaluation of gamma-aminobutyric acid analogues. New ligand for GABAB sites Journal of Medicinal Chemistry 30(4), 743-746 (1987).

2. Biscoe, T.J., and Fry, J.P. Some pharmacological studies on the spastic mouse British Journal of Pharmacology 75(1), 23-25 (1982).

3. Sakitani, K. The effects of centrally acting muscle relaxants on the intrathecal noradrenaline-induced facilitation of the flexor reflex mediated by group II afferent fibers in rats Japanese Journal of Pharmacology 63(3), 369-376 (1993).

4. Chou, R., Peterson, K., and Helfand, M. Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: A systematic review Journal of Pain and Symptom Management 28(2), 140-175 (2004).

5. Moore, E.M., and Boehm, S.L., II Site-specific microinjection of baclofen into the anterior ventral tegmental area reduces binge-like ethanol intake in male C57BL/6J mice Behav.Neurosci. 123(3), 555-563 (2009).

6. Lhuillier, L., Mombereau, C., Cryan, J.F., et al. GABAB receptor-positive modulation decreases selective molecular and behavioral effects of cocaine Neuropsychopharmacology 32(2), 388-398 (2007).

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