Pricing updated 2019-07-17. Prices are subject to change without notice.
(-)-Epinephrine is a natural neurotransmitter that is released from the adrenal medulla and activates adrenoceptors (Kis = 15, 735, and 3,970 nM for α1A-, β2-, and β1-adrenergic receptors, respectively).1,2,3 Through these receptors, (-)-epinephrine may induce either contraction or relaxation of vascular smooth muscle, depending on adrenoceptor subtype expression.3 Receptor-mediated actions of (-)-epinephrine are also relevant to blocking anaphylaxis, reversing cardiac arrest, and reducing bleeding in clinical trials.4,5,6
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Rothman, R.B., Vu, N., Partilla, J.S., et al. In vitro characterization of ephedrine-
Hoffmann, C., Leitz, M.R., Oberdorf-
3. Ahles, A., and Englehardt, S. Polymorphic variants of adrenoceptors: Pharmacology, physiology, and role in disease Pharmacol. Rev. 66(3), 598-637 (2014).
5. Chen, S.q. Advances in clinical studies of cardiopulmonary resuscitation World J.Emerg.Med. 6(2), 85-93 (2015).
6. Wilkins, T., Khan, N., Nabh, A., et al. Diagnosis and management of upper gastrointestinal bleeding American Family Physician 85(5), 469-476 (2012).