Pricing updated 2019-07-17. Prices are subject to change without notice.
UCM05 is an inhibitor of fatty acid synthase that strongly suppresses the growth of human breast cancer cell lines (IC50 = 21 µM for SK-BR-3 cells).1,2 It does not alter carnitine palmitoyltransferase 1 activity or induce weight loss in mice.1,2 UCM05 can reduce cleavage of poly(ADP-ribose) polymerase, phosphorylation of HER2, Akt, and ERK1/2, and growth of established xenografts in vivo.3 UCM05 also blocks the GTP-binding site of the cell division protein FtsZ from Bacillus, preventing bacterial division.4
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1. Puig, T., Turrado, C., Benhamú, B., et al. Novel inhibitors of fatty acid synthase with anticancer activity Clinical Cancer Research 15(24), 7608-7615 (2009).
Turrado, C., Puig, T., García-
Puig, T., Aguilar, H., Cufi, S., et al. A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-