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UCM05

Item № 19090
CAS № 1094451-90-7
Purity ≥95%
product image
                (CAS 1094451-90-7)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $25.00 0.00
     5 mg $45.00 0.00
     10 mg $175.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description
Synonyms
  • G28UCM

UCM05 is an inhibitor of fatty acid synthase that strongly suppresses the growth of human breast cancer cell lines (IC50 = 21 µM for SK-BR-3 cells).1,2 It does not alter carnitine palmitoyltransferase 1 activity or induce weight loss in mice.1,2 UCM05 can reduce cleavage of poly(ADP-ribose) polymerase, phosphorylation of HER2, Akt, and ERK1/2, and growth of established xenografts in vivo.3 UCM05 also blocks the GTP-binding site of the cell division protein FtsZ from Bacillus, preventing bacterial division.4

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Technical Information
Formal Name
3,4,5-trihydr3,4,5-trihydroxy-benzoic acid 1,1'-(1,3-naphthalenediyl) ester
CAS Number
1094451-90-7
Synonyms
  • G28UCM
Molecular Formula
C24H16O10
Formula Weight
464.4
Purity
≥95%
Formulation
A crystalline solid
λmax
223, 288 nm
SMILES
OC1=C(O)C(O)=CC(C(OC2=CC(C=CC=C3)=C3C(OC(C4=CC(O)=C(O)C(O)=C4)=O)=C2)=O)=C1
InChI Code
InChI=1S/C24H16O10/c25-16-6-12(7-17(26)21(16)29)23(31)33-14-5-11-3-1-2-4-15(11)20(10-14)34-24(32)13-8-18(27)22(30)19(28)9-13/h1-10,25-30H
InChI Key
KJCWIWDPTNVWRX-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Puig, T., Turrado, C., Benhamú, B., et al. Novel inhibitors of fatty acid synthase with anticancer activity Clinical Cancer Research 15(24), 7608-7615 (2009).

2. Turrado, C., Puig, T., García-Cárceles, J., et al. New synthetic inhibitors of fatty acid synthase with anticancer activity Journal of Medicinal Chemistry 55(11), 5013-5023 (2012).

3. Puig, T., Aguilar, H., Cufi, S., et al. A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines Breast Cancer Research 13(6), (2011).

4. Ruiz-Avila, L.B., Huecas, S., Artola, M., et al. Synthetic inhibitors of bacterial cell division targeting the GTP-binding site of FtsZ ACS Chemical Biology 8(9), 2072-2083 (2013).

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