We collect cookies for vital website function and to better serve our customers. By continuing to browse you agree to the storing of cookies on your device. See our privacy policy for details.

A-939572

Item № 19123
CAS № 1032229-33-6
Purity ≥98%
product image
                (CAS 1032229-33-6)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 mg $85.00 0.00
     10 mg $135.00 0.00
     50 mg $615.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description
Synonyms
  • SCD1 Inhibitor
  • Stearoyl-CoA Desaturase 1 Inhibitor

A-939572 inhibits stearoyl-CoA desaturase 1 (IC50 = 6.3 nM), a key enzyme for lipid metabolism that is expressed in human pluripotent stem cells (hPSCs).1 This compound has been used to induce cell death of hPSCs as well as to inhibit the proliferation of human non-small cell lung carcinoma H1299 cells in vitro.1,2

Recommended Products

Related Products
View Related Product Categories
Technical Information
Formal Name
4-(2-chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-piperidinecarboxamide
CAS Number
1032229-33-6
Synonyms
  • SCD1 Inhibitor
  • Stearoyl-CoA Desaturase 1 Inhibitor
Molecular Formula
C20H22ClN3O3
Formula Weight
387.9
Purity
≥98%
Formulation
A crystalline solid
SMILES
ClC1=CC=CC=C1OC2CCN(C(NC3=CC(C(NC)=O)=CC=C3)=O)CC2
InChI Code
InChI=1S/C20H22ClN3O3/c1-22-19(25)14-5-4-6-15(13-14)23-20(26)24-11-9-16(10-12-24)27-18-8-3-2-7-17(18)21/h2-8,13,16H,9-12H2,1H3,(H,22,25)(H,23,26)
InChI Key
DPYTYQFYDLYWHZ-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
Product Downloads

Download Product Insert

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Roongta, U.V., Pabalan, J.G., Wang, X., et al. Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy Mol. Cancer Res. 9(11), 1551-1561 (2011).

2. Ben-David, U., Gan, Q.F., Golan-Lev, T., et al. Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen Cell Stem Cell 12(2), 167-179 (2013).

Technical Support
Contact Us
  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Cayman Contract Services

We work with scientists to accelerate their research, drug discovery, and drug development needs through our expertise in the following areas:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

Toll Free: (800) 364-9897

(USA and Canada Only)

Fax: (734) 971-3640