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GSK621

Item № 19155
CAS № 1346607-05-3
Purity ≥98%
product image
                (CAS 1346607-05-3)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     500 µg $29.00 0.00
     1 mg $55.00 0.00
     5 mg $189.00 0.00
     10 mg $348.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description

GSK621 is an activator of AMP-activated protein kinase (AMPK). It has been shown to increase phosphorylation at AMPKα T172, a marker of AMPK activation, in both acute myeloid leukemia (AML) cell lines and primary AML samples.1 GSK621 is reported to reduce the proliferation of AML cell lines (IC50s = 13-30 μM), triggering autophagy via the eIF2α/ATF4 signaling pathway.1

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Technical Information
Formal Name
6-chloro-5-(2'-hydroxy-3'-methoxy[1,1'-biphenyl]-4-yl)-3-(3-methoxyphenyl)-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
CAS Number
1346607-05-3
Molecular Formula
C26H20ClN3O5
Formula Weight
489.9
Purity
≥98%
Formulation
A crystalline solid
λmax
273 nm
SMILES
COC1=CC=CC(N2C(C(N(C3=CC=C(C4=CC=CC(OC)=C4O)C=C3)C(Cl)=C5)=C5NC2=O)=O)=C1
InChI Code
InChI=1S/C26H20ClN3O5/c1-34-18-6-3-5-17(13-18)30-25(32)23-20(28-26(30)33)14-22(27)29(23)16-11-9-15(10-12-16)19-7-4-8-21(35-2)24(19)31/h3-14,31H,1-2H3,(H,28,33)
InChI Key
KURYSXLJGKKDHT-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Sujobert, P., Poulain, L., Paubelle, E., et al. Co-activation of AMPK and mTORC1 induces cytotoxicity in acute myeloid leukemia Cell Rep. 11(9), 1446-1457 (2015).

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