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AMG 900

Item № 19176
CAS № 945595-80-2
Purity ≥98%
product image
                (CAS 945595-80-2)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $35.00 0.00
     5 mg $158.00 0.00
     10 mg $285.00 0.00
     25 mg $640.00 0.00

Pricing updated 2019-06-19. Prices are subject to change without notice.

Description

Three Aurora kinases, A-C, are involved in phosphorylation events that are critical for the completion of mitosis. Their expression is elevated in a variety of human cancers. AMG 900 is an orally bioavailable, selective Aurora kinase inhibitor with IC50 values of 5, 4, and 1 nM for Aurora A, B, and C, respectively.1 It is greater than 10-fold selective for Aurora kinases over p38α, TYK2, JNK2, Met, and Tie2 (IC50s = 53, 220, 520, 550, and 650 nM, respectively).1 At 2-3 nM, AMG 900 has been shown to inhibit the proliferation of 26 different tumor cell lines in vitro, including cell lines resistant to either the antimitotic agent paclitaxel (Item No. 10461) or to other Aurora kinase inhibitors.1 Furthermore, AMG 900 is reported to be broadly active in multiple xenograft models, including three multidrug-resistant xenograft models, representing five tumor types.1

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Technical Information
Formal Name
N-[4-[[3-(2-amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)-1-phthalazinamine
CAS Number
945595-80-2
Molecular Formula
C28H21N7OS
Formula Weight
503.6
Purity
≥98%
Formulation
A crystalline solid
λmax
212, 325 nm
SMILES
NC1=NC=CC(C2=C(OC3=CC=C(NC4=C(C=CC=C5)C5=C(C6=CC(C)=CS6)N=N4)C=C3)N=CC=C2)=N1
InChI Code
InChI=1S/C28H21N7OS/c1-17-15-24(37-16-17)25-20-5-2-3-6-21(20)26(35-34-25)32-18-8-10-19(11-9-18)36-27-22(7-4-13-30-27)23-12-14-31-28(29)33-23/h2-16H,1H3,(H,32,35)(H2,29,31,33)
InChI Key
IVUGFMLRJOCGAS-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Payton, M., Bush, T.L., Chung, G., et al. Preclinical evaluation of AMG 900, a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines Cancer Research 70(23), 9846-9854 (2010).

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