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Xanthurenic Acid

Item № 19191
CAS № 59-00-7
Purity ≥95%
product image
                (CAS 59-00-7)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     500 mg $25.00 0.00
     1 g $40.00 0.00
     5 g $188.00 0.00
     10 g $350.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description
Synonyms
  • NSC 401570
  • Xanthurenate

Xanthurenic acid is formed upon tryptophan degradation by indoleamine 2,3-dioxygenase. It has been shown to be an endogenous Group II metabotropic glutamate receptor (mGluR2 and mGluR3) agonist and is implicated in the pathophysiology of schizophrenia.1,2 Xanthurenic acid has also been identified as an inducer of gametogenesis of P. falciparum, the parasite that causes malaria, and thus, is a target for the development of new methods to interrupt the transmission of malaria.3

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Technical Information
Formal Name
4,8-dihydroxy-2-quinolinecarboxylic acid
CAS Number
59-00-7
Synonyms
  • NSC 401570
  • Xanthurenate
Molecular Formula
C10H7NO4
Formula Weight
205.2
Purity
≥95%
Formulation
A crystalline solid
λmax
215, 218, 241, 329, 369 nm
SMILES
OC1=CC(C(O)=O)=NC2=C1C=CC=C2O
InChI Code
InChI=1S/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15)
InChI Key
FBZONXHGGPHHIY-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Copeland, C.S., Neale, S.A., and Salt, T.E. Actions of xanthurenic acid, a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus Neuropharmacology 66, 133-142 (2013).

2. Fazio, F., Lionetto, L., Curto, M., et al. Xanthurenic acid activates mGlu2/3 metabotropic glutamate receptors and is a potential trait marker for schizophrenia Sci.Rep. 5:17799, (2015).

3. Billker, O., Lindo, V., Panico, M., et al. Identification of xanthurenic acid as the putative inducer of malaria development in the mosquito Nature 392, 289-269 (1998).

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