Pricing updated 2019-07-17. Prices are subject to change without notice.
Xanthurenic acid is formed upon tryptophan degradation by indoleamine 2,3-dioxygenase. It has been shown to be an endogenous Group II metabotropic glutamate receptor (mGluR2 and mGluR3) agonist and is implicated in the pathophysiology of schizophrenia.1,2 Xanthurenic acid has also been identified as an inducer of gametogenesis of P. falciparum, the parasite that causes malaria, and thus, is a target for the development of new methods to interrupt the transmission of malaria.3
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1. Copeland, C.S., Neale, S.A., and Salt, T.E. Actions of xanthurenic acid, a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus Neuropharmacology 66, 133-142 (2013).
2. Fazio, F., Lionetto, L., Curto, M., et al. Xanthurenic acid activates mGlu2/3 metabotropic glutamate receptors and is a potential trait marker for schizophrenia Sci.Rep. 5:17799, (2015).
3. Billker, O., Lindo, V., Panico, M., et al. Identification of xanthurenic acid as the putative inducer of malaria development in the mosquito Nature 392, 289-269 (1998).