Syringic Acid (CAS 530-57-4) | Cayman Chemical
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Syringic Acid

Item № 19196
CAS № 530-57-4
Purity ≥98%
product image
                (CAS 530-57-4)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     10 g $25.00 0.00
     25 g $47.00 0.00
     50 g $69.00 0.00
     100 g $108.00 0.00

Pricing updated 2018-08-17. Prices are subject to change without notice.

Description
Synonyms
  • 3,5-dimethyl ether Gallic Acid
  • 3,5-dimethoxy-4-hydroxy Benzoic Acid
  • NSC 2129

Syringic acid is a naturally occurring O-methylated phenolic acid that can be enzymatically degraded by some bacteria as a source of methane or methanol.1 It is also a component of phenolic extracts from various plants that have antioxidant and prooxidant activities.2 Syringic acid has been shown to inhibit aldose reductase (IC50 = 213 µg/ml), proteasome activity, and cancer cell proliferation.3,4 Phenolic extracts containing syringic acid have been shown to inhibit α-amylase and α-glucosidase activities and reduce lipid peroxidation in vitro.5

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Technical Information
Formal Name
4-hydroxy-3,5-dimethoxy-benzoic acid
CAS Number
530-57-4
Synonyms
  • 3,5-dimethyl ether Gallic Acid
  • 3,5-dimethoxy-4-hydroxy Benzoic Acid
  • NSC 2129
Molecular Formula
C9H10O5
Formula Weight
198.2
Purity
≥98%
Formulation
A crystalline solid
λmax
218, 274 nm
SMILES
COC1=CC(C(O)=O)=CC(OC)=C1O
InChI Code
InChI=1S/C9H10O5/c1-13-6-3-5(9(11)12)4-7(14-2)8(6)10/h3-4,10H,1-2H3,(H,11,12)
InChI Key
JMSVCTWVEWCHDZ-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Hara, H., Masai, E., Katayama, Y., et al. The 4-oxalomesaconate hydratase gene, involved in the protocatechuate 4,5-cleavage pathway, is essential to vanillate and syringate degradation in Sphingomonas paucimobilis SYK-6. Journal of Bacteriology 182(24), 6950-6957 (2000).

2. Cotoras, M., Vivanco, H., Melo, R., et al. In vitro and in vivo evaluation of the antioxidant and prooxidant activity of phenolic compounds obtained from grape (Vitis vinifera) pomace. Molecules 19(12), 21154-21167 (2014).

3. Wei, X., Chen, D., Yi, Y., et al. Syringic acid extracted from Herba dendrobii prevents diabetic cataract pathogenesis by inhibiting aldose reductase activity. Evidence-Based Complementary and alternative Medicine 2012:426537, (2012).

4. Orabi, K.Y., Abazar, M.S., El Sayed, K.A., et al. Selective growth inhibition of human malignant melanoma cells by syringic acid-derived proteasome inhibitors. Cancer Cell Int. 13(1), (2013).

5. Oboh, G., Isaac, A.T., Akinyemi, A.J., et al. Inhibition of key enzymes linked to type 2 diabetes and sodium nitroprusside induced lipid peroxidation in rats' pancreas by phenolic extracts of avocado pear leaves and fruit. Int.J.Biomed.Sci. 10(3), 208-216 (2014).

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