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Cochlioquinone A

Item № 19440
CAS № 32450-25-2
Purity ≥99%
product image
                (CAS 32450-25-2)
     500 µg $239.00 0.00
     2.5 mg $956.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.


Cochlioquinone A, a bioactive compound isolated from D. sacchari and Bipolaris sp., is an inhibitor of diacylglycerol kinase (DGK; Ki = 3.1 µM) and diacylglycerol acyltransferase (DGAT; IC50 = 5.6 µM).1,2,3 It has been shown to reduce the concentration of phosphatidic acid in T cell lymphoma with an IC50 value of 3 µM.1 It is also reported to compete with macrophage inflammatory protein-1α for binding to human CCR5 chemokine receptors with an IC50 value of 11 µM.3

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Technical Information
Formal Name
CAS Number
Molecular Formula
Formula Weight
A yellow lyophilisate
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Room temperature in continental US; may vary elsewhere
≥ 2 years
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References & Product Citations
Product Description References

1. Machida, T., Higashi, K., and Ogawara, H. Cochlioquinone A, an inhibitor of diacylglycerol kinase J.Antibiot.(Tokyo) 48(10), 1076-1080 (1995).

2. Lee, H.B., Lim, C.H., Kwon, H.J., et al. Inhibitory activity of diacylglycerol acyltransferase by cochlioquinones A and A1 J.Antibiot.(Tokyo) 56(11), 967-969 (2003).

3. Yoganathan, K., Yang, L.K., Rossant, C., et al. Cochlioquinones and epi-cochlioquinones: Antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum J.Antibiot.(Tokyo) 57(1), 59-63 (2004).

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