Pricing updated 2019-07-17. Prices are subject to change without notice.
Cochlioquinone A, a bioactive compound isolated from D. sacchari and Bipolaris sp., is an inhibitor of diacylglycerol kinase (DGK; Ki = 3.1 µM) and diacylglycerol acyltransferase (DGAT; IC50 = 5.6 µM).1,2,3 It has been shown to reduce the concentration of phosphatidic acid in T cell lymphoma with an IC50 value of 3 µM.1 It is also reported to compete with macrophage inflammatory protein-1α for binding to human CCR5 chemokine receptors with an IC50 value of 11 µM.3
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1. Machida, T., Higashi, K., and Ogawara, H. Cochlioquinone A, an inhibitor of diacylglycerol kinase J.Antibiot.(Tokyo) 48(10), 1076-1080 (1995).
2. Lee, H.B., Lim, C.H., Kwon, H.J., et al. Inhibitory activity of diacylglycerol acyltransferase by cochlioquinones A and A1 J.Antibiot.(Tokyo) 56(11), 967-969 (2003).
Yoganathan, K., Yang, L.K., Rossant, C., et al. Cochlioquinones and epi-