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YLF-466D

Item № 19475
CAS № 1273323-67-3
Purity ≥98%
product image
                (CAS 1273323-67-3)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $85.00 0.00
     5 mg $383.00 0.00
     10 mg $613.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

Description

YLF-466D is an orally bioavailable activator of AMP-activated protein kinase (AMPK), an enzyme involved in regulation of cellular energy homeostasis.1 YLF-466D activates AMPK at a concentration of 150 µM in platelets. It inhibits platelet aggregation induced by thrombin, ADP, and collagen (IC50s = 84, 55, and 87 µM, respectively) and inhibits aggregation of whole blood. YLF-466D leads to dose-dependent glucose uptake in L6 myotubes and, at a dose of 150 mg/kg, improves glucose tolerance in two mouse models of diabetes.2,3

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Technical Information
Formal Name
3-[[(3E)-3-[(4-chlorophenyl)phenylmethylene]-2,3-dihydro-2-oxo-1H-indol-1-yl]methyl]-benzoic acid
CAS Number
1273323-67-3
Molecular Formula
C29H20ClNO3
Formula Weight
465.9
Purity
≥98%
Formulation
A crystalline solid
λmax
341 nm
SMILES
O=C1N(CC2=CC=CC(C(O)=O)=C2)C3=C(C=CC=C3)/C1=C(C4=CC=CC=C4)\C5=CC=C(Cl)C=C5
InChI Code
InChI=1S/C29H20ClNO3/c30-23-15-13-21(14-16-23)26(20-8-2-1-3-9-20)27-24-11-4-5-12-25(24)31(28(27)32)18-19-7-6-10-22(17-19)29(33)34/h1-17H,18H2,(H,33,34)/b27-26+
InChI Key
BPBOVHROVFJFAH-CYYJNZCTSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Liu, Y., Park, J.-M., Oh, S.-J., et al. Antiplatelet effect of a newly developed AMP-activated protein kinase activator YLF-466D Eur. J. Pharmacol. 760, 81-87 (2015).

2. Yu, L.-F., Lo, Y.-Y., Su, M.-B., et al. Development of novel alkene oxindole derivatives as orally efficacious AMP-activated protein kinase activators ACS Med. Chem. Lett. 4(5), 475-480 (2013).

3. Li, Y.-Y., Yu, L.-F., Zhang, L.-N., et al. Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice Toxicol. Appl. Pharmacol. 273(2), 325-334 (2013).

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