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Amorfrutin B

Item № 19618
CAS № 78916-42-4
Purity ≥97%
product image
                (CAS 78916-42-4)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     500 µg $135.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description

Amorfrutin B is a partial agonist of the peroxisome proliferator-activated receptor γ (PPARγ; Ki = 19 nM and EC50 = 73 nM) that was first isolated from A. fruticosa.1 It binds to PPARα and PPARβ/δ with Ki values of 2.6 and 1.7 µM, respectively.1 In insulin-resistant mice, 100 mg/kg/day amorfrutin B is reported to improve insulin sensitivity, glucose tolerance, and plasma lipid concentrations after two weeks of treatment.1

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Technical Information
Formal Name
3-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-2-hydroxy-4-methoxy-6-(2-phenylethyl)-benzoic acid
CAS Number
78916-42-4
Molecular Formula
C26H32O4
Formula Weight
408.5
Purity
≥97%
Formulation
A solid
SMILES
OC(C(C(O)=C(C/C=C(C)/CC/C=C(C)/C)C(OC)=C1)=C1CCC2=CC=CC=C2)=O
InChI Code
InChI=1S/C26H32O4/c1-18(2)9-8-10-19(3)13-16-22-23(30-4)17-21(24(25(22)27)26(28)29)15-14-20-11-6-5-7-12-20/h5-7,9,11-13,17,27H,8,10,14-16H2,1-4H3,(H,28,29)/b19-13+
InChI Key
DKNIJLWIVUCTHW-CPNJWEJPSA-N
Origin
  • Plant/Amorpha fruticosa

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Weidner, C., Wowro, S.J., Freiwald, A., et al. Amorfrutin B is an efficient natural peroxisome proliferator-activated receptor gamma (PPARγ) agonist with potent glucose-lowering properties Diabetologia 56(8), 1802-1812 (2013).

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