Formulation: A 1 mg/ml solution in methanol
Pricing updated 2018-05-27. Prices are subject to change without notice.
MT-45 (hydrochloride) (CRM) (Item No. 19737) is a certified reference material that is structurally categorized as a piperazine. It displays potent analgesic activity comparable to morphine (Item No. ISO60147) despite being structurally unrelated to most other opioids.1 In particular, the S-(+)-enantiomer of MT-45 (Item No. 15128) displays analgesic potency similar to that of morphine (ED50s = 0.35 and 0.4 μg/kg, i.v., respectively in Haffner’s mouse tail-pinch method), whereas the R-(−)-isomer (Item No. 15127) displays comparatively weak activity (ED50 = 2 μg/kg, i.v.).2 Furthermore, the analgesic activity of the racemate (±) is reported to be more potent (ED50 = 0.12 μg/kg, i.v.) than its enantiomorphic pairs.2 MT-45 has been used as a lead compound to develop a large group of potent opioid drugs with agonist or antagonist activities particular to the various opioid receptor subtypes.3 This product is intended for forensic and research applications.
Cayman Chemical products containing Certified Reference Material (CRM) in the name are highly qualified materials manufactured and tested to meet ISO/IEC 17025 and ISO Guide 34 international guidelines for reference materials. These materials are tested using validated analytical methods on qualified instrumentation to ensure traceability to SI units of measure. Cayman’s CRMs are tested for Homogeneity and Stability and are provided with a certificate stating the CRM property value(s) along with the combined uncertainty of the property value(s). These materials are intended for quantitative applications where quantitative accuracy and uncertainty are critical. Cayman Chemical is committed to providing quality products to its customers as evidenced by its accreditation to the ISO/IEC 17025 and ISO Guide 34 standards. All traceable CRMs may be distinguished by their CofAs and can be downloaded below using the batch number located on the product label. For a representative CofA please contact our technical support.
Warning - this product is not for human or veterinary use.
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Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.
Natsuka, K., Nakamura, H., Uno, H., et al. Studies on 1-
Fujimura, H., Tsurumi, K., Nozaki, M., et al. Analgesic activity and opiate receptor binding of 1-
Natsuka, K., Nakamura, H., Nishikawa, Y., et al. Synthesis and structure-