MT-45 (hydrochloride) (CRM) (CAS 57314-55-3) | Cayman Chemical
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MT-45 (hydrochloride) (CRM)

Item № 19737
CAS № 57314-55-3

Formulation:  A 1 mg/ml solution in methanol

     1 mg $97.00 0.00

Pricing updated 2018-05-25. Prices are subject to change without notice.

  • Manufactured under ISO/IEC17025:2005 and ISO Guide 34:2009 specifications
  • This is a Certified Reference Material (CRM) intended for use as a quantitative analytical reference standard
  • Bulk material is available for academic research at qualified institutions; please contact our sales department for pricing
  • I-C6
  • NSC 299236

MT-45 (hydrochloride) (CRM) (Item No. 19737) is a certified reference material that is structurally categorized as a piperazine. It displays potent analgesic activity comparable to morphine (Item No. ISO60147) despite being structurally unrelated to most other opioids.1 In particular, the S-(+)-enantiomer of MT-45 (Item No. 15128) displays analgesic potency similar to that of morphine (ED50s = 0.35 and 0.4 μg/kg, i.v., respectively in Haffner’s mouse tail-pinch method), whereas the R-(−)-isomer (Item No. 15127) displays comparatively weak activity (ED50 = 2 μg/kg, i.v.).2 Furthermore, the analgesic activity of the racemate (±) is reported to be more potent (ED50 = 0.12 μg/kg, i.v.) than its enantiomorphic pairs.2 MT-45 has been used as a lead compound to develop a large group of potent opioid drugs with agonist or antagonist activities particular to the various opioid receptor subtypes.3 This product is intended for forensic and research applications.

Cayman Chemical products containing Certified Reference Material (CRM) in the name are highly qualified materials manufactured and tested to meet ISO/IEC 17025 and ISO Guide 34 international guidelines for reference materials. These materials are tested using validated analytical methods on qualified instrumentation to ensure traceability to SI units of measure. Cayman’s CRMs are tested for Homogeneity and Stability and are provided with a certificate stating the CRM property value(s) along with the combined uncertainty of the property value(s). These materials are intended for quantitative applications where quantitative accuracy and uncertainty are critical. Cayman Chemical is committed to providing quality products to its customers as evidenced by its accreditation to the ISO/IEC 17025 and ISO Guide 34 standards. All traceable CRMs may be distinguished by their CofAs and can be downloaded below using the batch number located on the product label. For a representative CofA please contact our technical support.

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RMs and CRMs produced to accreditation standards: ISO/IEC 17025:2005 · ISO Guide 34:2009
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Technical Information
Formal Name
1-cyclohexyl-4-(1,2-diphenylethyl)-piperazine, dihydrochloride
CAS Number
  • I-C6
  • NSC 299236
Molecular Formula
C24H32N2 • 2HCl
Formula Weight
A 1 mg/ml solution in methanol
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Wet ice in continental US; may vary elsewhere
≥ 1 year
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References & Product Citations
Product Description References

1. Natsuka, K., Nakamura, H., Uno, H., et al. Studies on 1-substituted 4-(1,2-diphenylethyl)piperazine derivatives and their analgesic activities. 1. Journal of Medicinal Chemistry 18(12), 1240-1244 (1975).

2. Fujimura, H., Tsurumi, K., Nozaki, M., et al. Analgesic activity and opiate receptor binding of 1-cyclohexyl-4-(1,2-diphenylethyl)piperazine. Japanese Journal of Pharmacology 28(3), 505-506 (1978).

3. Natsuka, K., Nakamura, H., Nishikawa, Y., et al. Synthesis and structure-activity relationships of 1-substituted 4-(1,2-diphenylethyl)piperazine derivatives having narcotic agonist and antagonist activity. Journal of Medicinal Chemistry 30(10), 1779-1787 (1987).

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