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Ferulic Acid

Item № 19871
CAS № 1135-24-6
Purity ≥98%
product image
                (CAS 1135-24-6)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 g $19.00 0.00
     10 g $27.00 0.00
     25 g $38.00 0.00
     50 g $67.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description
Synonyms
  • Coniferic Acid
  • 4-hydroxy-3-Methoxycinnamic Acid
  • NSC 2821
  • NSC 51986
  • NSC 674320

Ferulic acid is a hydroxycinnamic acid with antioxidant properties that is present in the cell walls of plants such as wheat, rice, peanuts, coffee, oranges, and apples. Its antioxidant activity has been shown to act synergistically with vitamins C and E, reducing thymine dimer formation in skin exposed to UVB irradiation.1,2 Animal and in vitro studies suggest that ferulic acid and its derivatives may have direct antitumor activity and pro-apoptotic effects in cancer cells.3,4 Ferulic acid has also been examined in the process of skin lightening due to its ability to inhibit tyrosinase, the key enzyme in melanogenesis.5

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Technical Information
Formal Name
3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid
CAS Number
1135-24-6
Synonyms
  • Coniferic Acid
  • 4-hydroxy-3-Methoxycinnamic Acid
  • NSC 2821
  • NSC 51986
  • NSC 674320
Molecular Formula
C10H10O4
Formula Weight
194.2
Purity
≥98%
Formulation
A crystalline solid
λmax
218, 234, 323 nm
SMILES
COC1=C(O)C=CC(/C=C/C(O)=O)=C1
InChI Code
InChI=1S/C10H10O4/c1-14-9-6-7(2-4-8(9)11)3-5-10(12)13/h2-6,11H,1H3,(H,12,13)/b5-3+
InChI Key
KSEBMYQBYZTDHS-HWKANZROSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
Room temperature
Shipping
Ambient in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Lin, F.-H., Lin, J.-Y., Gupta, R.D., et al. Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin J. Invest. Dermatol. 125(4), 826-832 (2005).

2. Di Domenico, F., Perluigi, M., Foppoli, C., et al. Protective effect of ferulic acid ethyl ester against oxidative stress mediated by UVB irradiation in human epidermal melanocytes Free Radical Research 43(4), 365-375 (2009).

3. Hosoda, A., Ozaki, Y., Kashiwada, A., et al. Syntheses of ferulic acid derivatives and their suppressive effects on cyclooxygenase-2 promoter activity Bioorganic & Medicinal Chemistry 10, 1189-1196 (2002).

4. Huang, M.T., Smart, R.C., Wong, C., et al. Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate Cancer Research 48, 5941-5946 (1988).

5. Smit, N., Vicanova, J., and Pavel, S. The hunt for natural skin whitening agents International Journal of Molecular Sciences 10(12), 5326-5349 (2009).

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