We collect cookies for vital website function and to better serve our customers. By continuing to browse you agree to the storing of cookies on your device. See our privacy policy for details.

Leukotriene B4

Item № 20110
CAS № 71160-24-2
Purity ≥97%
product image
                (CAS 71160-24-2)
     25 µg $118.00 0.00
     50 µg $224.00 0.00
     100 µg $425.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

  • LTB4

Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway.1,2,3 It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. In subnanomolar ranges (3.9 x 10−10 M), LTB4 causes chemotaxis and chemokinesis in human polymorphonuclear leukocytes.4 At higher concentrations, (1.0 x 10−7 M), LTB4 leads to neutrophil aggregation and degranulation as well as superoxide anion production.4,5

Recommended Products

Related Products
View Related Product Categories
View Screening Libraries with Leukotriene B4
Technical Information
Formal Name
5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid
CAS Number
  • LTB4
Molecular Formula
Formula Weight
A solution in ethanol
270 nm
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Wet ice in continental US; may vary elsewhere
≥ 1 year
Downloads & Resources
Product Downloads

Download Product Insert

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Rådmark, O., Malmsten, C., Samuelsson, B., et al. Leukotriene A: Stereochemistry and enzymatic conversion to leukotriene B Biochem. Biophys. Res. Commun. 92(3), 954-961 (1980).

2. Ford-Hutchinson, A.W., Bray, M.A., Doig, M.V., et al. Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes Nature 286(5770), 264-265 (1980).

3. McGee, J., and Fitzpatrick, F. Enzymatic hydration of leukotriene A4. Purification and characterization of a novel epoxide hydrolase from human erythrocytes J. Biol. Chem. 260(23), 12832-12837 (1985).

4. Ford-Hutchinson, A.W. Leukotriene B4 in inflammation Crit. Rev. Immunol. 10(1), 1-12 (1990).

5. McMillan, R.M., and Foster, S.J. Leukotriene B4 and inflammatory disease Agents Actions 24(1-2), 114-119 (1988).

Product Citations

Sorgi, C.A., Peti, A.P.F., Petta, T., et al. Comprehensive high-resolution multiple-reaction monitoring mass spectrometry for targeted eicosanoid assays Sci. Data 5:180167, (2018).

Archambault, A.-S., Turcotte, C., Martin, C., et al. Comparison of eight 15-lipoxygenase (LO) inhibitors on the biosynthesis of 15-LO metabolites by human neutrophils and eosinophils PLOS One 13(8), (2018).

Levy, B.D., De Sanctis, G.T., Devchand, P.R., et al. Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A4 Nature Medicine 8(9), 1018-1023 (2002).

Show all 4
Technical Support
Contact Us
  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Cayman Contract Services

We work with scientists to accelerate their research, drug discovery, and drug development needs through our expertise in the following areas:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

Toll Free: (800) 364-9897

(USA and Canada Only)

Fax: (734) 971-3640