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Leukotriene B4

Item № 20110
CAS № 71160-24-2
Purity ≥97%
product image
                (CAS 71160-24-2)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     25 µg $118.00 0.00
     50 µg $224.00 0.00
     100 µg $425.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

Description
Synonyms
  • LTB4

Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway.1,2,3 It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. In subnanomolar ranges (3.9 x 10−10 M), LTB4 causes chemotaxis and chemokinesis in human polymorphonuclear leukocytes.4 At higher concentrations, (1.0 x 10−7 M), LTB4 leads to neutrophil aggregation and degranulation as well as superoxide anion production.4,5

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Technical Information
Formal Name
5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid
CAS Number
71160-24-2
Synonyms
  • LTB4
Molecular Formula
C20H32O4
Formula Weight
336.5
Purity
≥97%
Formulation
A solution in ethanol
λmax
270 nm
SMILES
CCCCC/C=C\C[C@@H](O)/C=C/C=C\C=C\[C@@H](O)CCCC(=O)O
InChI Code
InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1
InChI Key
VNYSSYRCGWBHLG-AMOLWHMGSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 1 year
Downloads & Resources
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Additional Information

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References & Product Citations
Product Description References

1. Rådmark, O., Malmsten, C., Samuelsson, B., et al. Leukotriene A: Stereochemistry and enzymatic conversion to leukotriene B Biochem. Biophys. Res. Commun. 92(3), 954-961 (1980).

2. Ford-Hutchinson, A.W., Bray, M.A., Doig, M.V., et al. Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes Nature 286(5770), 264-265 (1980).

3. McGee, J., and Fitzpatrick, F. Enzymatic hydration of leukotriene A4. Purification and characterization of a novel epoxide hydrolase from human erythrocytes J. Biol. Chem. 260(23), 12832-12837 (1985).

4. Ford-Hutchinson, A.W. Leukotriene B4 in inflammation Crit. Rev. Immunol. 10(1), 1-12 (1990).

5. McMillan, R.M., and Foster, S.J. Leukotriene B4 and inflammatory disease Agents Actions 24(1-2), 114-119 (1988).

Product Citations

Sorgi, C.A., Peti, A.P.F., Petta, T., et al. Comprehensive high-resolution multiple-reaction monitoring mass spectrometry for targeted eicosanoid assays Sci. Data 5:180167, (2018).

Archambault, A.-S., Turcotte, C., Martin, C., et al. Comparison of eight 15-lipoxygenase (LO) inhibitors on the biosynthesis of 15-LO metabolites by human neutrophils and eosinophils PLOS One 13(8), (2018).

Levy, B.D., De Sanctis, G.T., Devchand, P.R., et al. Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A4 Nature Medicine 8(9), 1018-1023 (2002).

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