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Item № 20930
CAS № 485-63-2
Purity ≥98%
product image
                (CAS 485-63-2)
     25 mg $35.00 0.00
     50 mg $67.00 0.00
     100 mg $119.00 0.00
     250 mg $245.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

  • 3'-hydroxy Daidzein
  • 3’,4’,7-THIF

3',4',7-Trihydroxyisoflavone is a natural isoflavonoid that has antioxidant activity.1 It can be produced by the metabolism of daidzein (Item No. 10005166) or daidzin (Item No. 13202).2,3 3',4',7-Trihydroxyisoflavone inhibits several signaling pathways in cells, including tyrosinase-mediated melanin formation (IC50 = 5.2 µM), casein kinase II-mediated phosphorylation of 60S acidic ribosomal P proteins, and cyclin-dependent, kinase-regulated cell proliferation.4,5,6

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Technical Information
Formal Name
CAS Number
  • 3'-hydroxy Daidzein
  • 3’,4’,7-THIF
Molecular Formula
Formula Weight
A crystalline solid
219, 249, 261, 293 nm
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Wet ice in continental US; may vary elsewhere
≥ 2 years
Downloads & Resources
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Additional Information

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References & Product Citations
Product Description References

1. Komiyama, K., Funayama, S., Anraku, Y., et al. Isolation of isoflavonoids possessing antioxidant activity from the fermentation broth of Streptomyces sp J. Antibiot. (Tokyo) 42(9), 1344-1349 (1989).

2. Choi, K.-Y., Kim, T.-j., Koh, S.-K., et al. A-ring ortho-specific monohydroxylation of daidzein by cytochrome P450s of Nocardia farcinica IFM10152 Biotechnol. J. 4(11), 1586-1595 (2009).

3. Yasuda, T., and Ohsawa, K. Urinary metabolites of daidzin orally administered in rats Biol. Pharm. Bull. 21(9), 953-957 (1998).

4. Park, J.-S., Kim, D.H., Lee, J.K., et al. Natural ortho-dihydroxyisoflavone derivatives from aged Korean fermented soybean paste as potent tyrosinase and melanin formation inhibitors Bioorg. Med. Chem. Lett. 20(3), 1162-1164 (2010).

5. Maekawa, T., Kosuge, S., Sakamoto, S., et al. Biochemical characterization of 60S acidic ribosomal P proteins associated with CK-II from bamboo shoots and potent inhibitors of their phosphorylation in vitro Biol. Pharm. Bull. 22(7), 667-673 (1999).

6. Lee, D.E., Lee, K.Q., Song, N.R., et al. 7,3',4'-Trihydroxyisoflavone inhibits epidermal growth factor-induced proliferation and transformation of JB6 P+ mouse epidermal cells by suppressing cyclin-dependent kinases and phosphatidylinositol 3-kinase J. Biol. Chem. 285(28), 21458-21466 (2010).

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