Pricing updated 2019-07-17. Prices are subject to change without notice.
ML-356 is an inhibitor of the thioesterase domain of fatty acid synthase (FASN-TE; IC50 = 334 nM).1 It is selective for FASN over a number of other human thioesterases expressed in tumor cells, and selective for FASN-TE over its most closely related human homolog, ACOT4.1 In cells, ML-356 has been shown to block the biosynthesis of palmitate, the end product of FASN.1
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Ardecky, R., Hedrick, M.P., Gosalia, P., et al. Selective inhibitors of FAS-