We collect cookies for vital website function and to better serve our customers. By continuing to browse you agree to the storing of cookies on your device. See our privacy policy for details.

Amorfrutin A

Item № 21106
CAS № 80489-90-3
Purity ≥97%
product image
                (CAS 80489-90-3)
     500 µg $185.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

  • Amorfrutin 1

Amorfrutin A is an isoprenoid-substituted benzoic acid natural product found in the fruit of A. fruticosa and G. foetida that exhibits antidiabetic effects. It binds to PPARγ with a Ki of 0.236 µM and activates a PPARγ gene reporter assay with an EC50 value of 0.458 µM.1 In high-fat diet-induced obese (DIO) mice, amorfrutin A (100 mg/kg/day) enhanced glucose tolerance and insulin sensitivity, while decreasing plasma triglycerides, free fatty acids, insulin, and glucose concentrations.1 Amorfrutin A inhibits TNF-α-induced expression of a number of inflammatory genes such as COX-2, IL-1β, MCP-1, MIP-2, MIP-3α, MMP-9, and IL-8 through inhibition of both NF-κB and PPARγ activity with efficacy at 5-20 µM.2,3

Recommended Products

Related Products
View Related Product Categories
Technical Information
Formal Name
2-hydroxy-4-methoxy-3-(3-methyl-2-buten-1-yl)-6-(2-phenylethyl)-benzoic acid
CAS Number
  • Amorfrutin 1
Molecular Formula
Formula Weight
A solid
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Room temperature in continental US; may vary elsewhere
≥ 2 years
Downloads & Resources
Product Downloads

Download Product Insert

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Weidner, C., de Groot, J.C., Prasad, A., et al. Amorfrutins are potent antidiabetic dietary natural products Proc. Natl. Acad. Sci. USA 109(19), 7257-7262 (2012).

2. Shi, H., Ma, J., Mi, C., et al. Amorfrutin A inhibits TNF-α-induced NF-κB activation and NF-κB-regulated target gene products Int. Immunopharmacol. 21(1), 56-62 (2014).

3. Fuhr, L., Rousseau, M., Plauth, A., et al. Amorfrutins are natural PPARg agonists with potent anti-inflammatory properties J. Nat. Prod. 78(5), 1160-1164 (2015).

Technical Support
Contact Us
  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Cayman Contract Services

We work with scientists to accelerate their research, drug discovery, and drug development needs through our expertise in the following areas:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

Toll Free: (800) 364-9897

(USA and Canada Only)

Fax: (734) 971-3640