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PT1

Item № 21335
CAS № 331002-70-1
Purity ≥95%
product image
                (CAS 331002-70-1)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $29.00 0.00
     5 mg $94.00 0.00
     10 mg $157.00 0.00
     25 mg $363.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

Description

PT1 is an activator of AMP-activated protein kinase (AMPK) that directly activates the inactive truncated forms of AMPK monomers α1335, α1394, and α2398 in a dose-dependent manner (EC50s = ~ 8, 8, and 12 µM, respectively).1 It stimulates the α1β1γ1 AMPK heterotrimer with an EC50 value of 0.3 μM.1 PT1 dose-dependently increases phosphorylation of AMPK and its downstream substrate, acetyl-CoA carboxylase, without increasing the cellular AMP:ATP ratio in L6 myotubes.1 In HepG2 liver cells, PT1 lowers lipid content through AMPK activation.{Pan} PT1 induces autophagy in cardiomyocytes after oxygen glucose deprivation/reoxygenation, resulting in improved cell survival.2

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Technical Information
Formal Name
2-chloro-5-[[5-[[5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-4-oxo-2-thiazolyl]amino]-benzoic acid
CAS Number
331002-70-1
Molecular Formula
C23H16ClN3O6S
Formula Weight
497.9
Purity
≥95%
Formulation
A crystalline solid
λmax
272, 399 nm
SMILES
ClC1=CC=C(NC(S/C2=C/C3=CC=C(C4=CC(C)=C(C)C=C4[N+]([O-])=O)O3)=NC2=O)C=C1C(O)=O
InChI Code
InChI=1S/C23H16ClN3O6S/c1-11-7-16(18(27(31)32)8-12(11)2)19-6-4-14(33-19)10-20-21(28)26-23(34-20)25-13-3-5-17(24)15(9-13)22(29)30/h3-10H,1-2H3,(H,29,30)(H,25,26,28)/b20-10+
InChI Key
RTHRCOIONCZINZ-KEBDBYFISA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Pang, T., Zhang, Z.-S., Gu, M., et al. Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells J. Biol. Chem. 283(23), 16051-16060 (2008).

2. Huang, L., Dai, K.H., Chen, M., et al. The AMPK agonist PT1 and mTOR inhibitor 3HOI-BA-01 protect cardiomyocytes after ischemia through induction of autophagy J. Cardiovasc. Pharmacol. Ther. 21(1), 70-81 (2016).

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