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MK-3102

Item № 21454
CAS № 1226781-44-7
Purity ≥98%
product image
                (CAS 1226781-44-7)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $45.00 0.00
     5 mg $180.00 0.00
     10 mg $324.00 0.00
     25 mg $729.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description
Synonyms
  • Omarigliptin

MK-3102 is a potent, reversible, and competitive inhibitor of dipeptidyl peptidase 4 (DPP-4; IC50 = 1.6 nM; Ki = 0.8 nM).1 It is selective for DPP-4 over 168 proteases, ion channels, and enzymes with IC50 values greater than 10 µM in all assays. MK-3102 significantly reduces blood glucose levels in a dose-dependent manner in vivo in rats. It also has a long half-life (11 and 22 hours in rat and dog, respectively) making it suitable for once weekly dosing. Clinical trials demonstrate that formulations containing MK-3102 reduce plasma glucose and HbA1c in patients with type 2 diabetes mellitus (T2DM).

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Technical Information
Formal Name
(2R,3S,5R)-2-(2,5-difluorophenyl)-5-[2,6-dihydro-2-(methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine
CAS Number
1226781-44-7
Synonyms
  • Omarigliptin
Molecular Formula
C17H20F2N4O3S
Formula Weight
398.4
Purity
≥98%
Formulation
A crystalline solid
λmax
268 nm
SMILES
FC1=CC([C@@H]2[C@@H](N)C[C@@H](N3CC4=NN(S(=O)(C)=O)C=C4C3)CO2)=C(F)C=C1
InChI Code
InChI=1S/C17H20F2N4O3S/c1-27(24,25)23-7-10-6-22(8-16(10)21-23)12-5-15(20)17(26-9-12)13-4-11(18)2-3-14(13)19/h2-4,7,12,15,17H,5-6,8-9,20H2,1H3/t12-,15+,17-/m1/s1
InChI Key
MKMPWKUAHLTIBJ-ISTRZQFTSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Biftu, T., Sinha-Roy, R., Chen, P., et al. Omarigliptin (MK-3102): A novel long-acting DPP‑4 inhibitor for once-weekly treatment of Type 2 Diabetes J. Med. Chem. 57(8), 3205-3212 (2014).

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