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ZLN024

Item № 21644
CAS № 723249-01-2
Purity ≥98%
product image
                (CAS 723249-01-2)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 mg $78.00 0.00
     10 mg $130.00 0.00
     25 mg $270.00 0.00
     50 mg $490.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description

ZLN024 is an allosteric activator of AMP-activated protein kinase (AMPK) heterotrimers (EC50s = 0.42 and 0.95 µM for α1β1γ1 and α2β1γ1, respectively).1 Activation of AMPK by ZLN024 requires phosphorylation of AMPK on Thr172, and ZLN024 protects Thr172 from dephosphorylation by protein phosphatase 2Cα.1 ZLN024 stimulates glucose uptake and fatty acid oxidation in L6 myotubes. In primary hepatocytes, ZLN024 decreases fatty acid synthesis and glucose output.1 ZLN024 reduces liver triacylglycerol and total cholesterol content and improves glucose tolerance in db/db mice.1

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Technical Information
Formal Name
2-[[2-(2-bromo-4-methylphenoxy)ethyl]thio]-pyrimidine
CAS Number
723249-01-2
Molecular Formula
C13H13BrN2OS
Formula Weight
325.2
Purity
≥98%
Formulation
A crystalline solid
λmax
249, 282 nm
SMILES
CC1=CC(Br)=C(OCCSC2=NC=CC=N2)C=C1
InChI Code
InChI=1S/C13H13BrN2OS/c1-10-3-4-12(11(14)9-10)17-7-8-18-13-15-5-2-6-16-13/h2-6,9H,7-8H2,1H3
InChI Key
KWJRSHZSULRJHE-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Zhang, L.-N., Xu, L., Zhou, H.-Y., et al. Novel small-molecule AMP-activated protein kinase allosteric activator with beneficial effects in db/db mice. PLoS One 8(8), e72092 (2013).

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