Pricing updated 2019-07-18. Prices are subject to change without notice.
Vimentin is a cytoskeleton intermediate filament protein present in cells of mesenchymal origin, including leukocytes, endothelial cells, and smooth muscle cells.1 It is subject to citrullination by peptidyl arginine deiminase 2 (PAD2; Item No. 10785) under high calcium concentrations, which can occur during macrophage apoptosis.2 Citrullinated vimentin has been shown to have a role in the production of anti-citrullinated protein antibodies (ACPAs).2,3 ACPAs against citrullinated proteins, such as vimentin, are considered to be highly specific markers for rheumatoid arthritis and other autoimmune diseases.3
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1. Eriksson, J.E., Dechat, T., Grin, B., et al. Introducing intermediate filaments: From discovery to disease J. Clin. Invest. 119(7), 1763-1771 (2009).
Asaga, H., Yamada, M., and Senshu, T. Selective deimination of vimentin in calcium ionophore-
Soós, L., Szekanecz, Z., Szabó, Z., et al. Clinical evaluation of anti-