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Citrullinated Vimentin (human recombinant)

Item № 21942
Purity ≥55 %
     100 µg $448.00 0.00

Pricing updated 2019-07-18. Prices are subject to change without notice.


Vimentin is a cytoskeleton intermediate filament protein present in cells of mesenchymal origin, including leukocytes, endothelial cells, and smooth muscle cells.1 It is subject to citrullination by peptidyl arginine deiminase 2 (PAD2; Item No. 10785) under high calcium concentrations, which can occur during macrophage apoptosis.2 Citrullinated vimentin has been shown to have a role in the production of anti-citrullinated protein antibodies (ACPAs).2,3 ACPAs against citrullinated proteins, such as vimentin, are considered to be highly specific markers for rheumatoid arthritis and other autoimmune diseases.3

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Technical Information
≥55 %
Human recombinant vimentin purified from E. coli
Amino Acids
Molecular Weight
53.5 kDa
10 mM Tris, pH 8.0
UniProt Accession №

Warning - this product is not for human or veterinary use.

Shipping & Storage
Dry ice in continental US; may vary elsewhere
≥ 1 year
Downloads & Resources
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Eriksson, J.E., Dechat, T., Grin, B., et al. Introducing intermediate filaments: From discovery to disease J. Clin. Invest. 119(7), 1763-1771 (2009).

2. Asaga, H., Yamada, M., and Senshu, T. Selective deimination of vimentin in calcium ionophore-induced apoptosis of mouse peritoneal macrophages Biochem. Biophys. Res. Commun. 243(3), 641-646 (1998).

3. Soós, L., Szekanecz, Z., Szabó, Z., et al. Clinical evaluation of anti-mutated citrullinated vimentin by ELISA in rheumatoid arthritis J. Rheumatol. 34(8), 1658-1663 (2007).

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