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MBX-2982

Item № 22206
CAS № 1037792-44-1
Purity ≥98%
product image
                (CAS 1037792-44-1)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 mg $125.00 0.00
     10 mg $225.00 0.00
     25 mg $500.00 0.00
     50 mg $695.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description

MBX-2982 is a agonist of GPR119.1 It reduces nuclear and total protein levels of sterol regulatory element binding protein 1 (SREBP-1) in HepG2 cells and rat primary hepatocytes under high-glucose and -insulin conditions and increases phosphorylation of the inhibitory form, SREBP-1c. MBX-2982 (10 mg/kg) inhibits hepatic lipid accumulation in wild-type, but not GPR119 knockout, mice fed a high-fat diet. It also increases plasma levels of glucagon-like peptide 1 (GLP-1; Item No. 24460) in mice when administered at a dose of 10 mg/kg prior to, and to a greater extent following, glucose administration.2 MBX-2982 increases glucokinase activity in an enzyme assay with an EC50 value of 45.11 µM.3

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Technical Information
Formal Name
5-ethyl-2-[4-[4-[[4-(1H-tetrazol-1-yl)phenoxy]methyl]-2-thiazolyl]-1-piperidinyl]-pyrimidine
CAS Number
1037792-44-1
Molecular Formula
C22H24N8OS
Formula Weight
448.5
Purity
≥98%
Formulation
A crystalline solid
λmax
250 nm
SMILES
CCC1=CN=C(N2CCC(C3=NC(COC4=CC=C(N5N=NN=C5)C=C4)=CS3)CC2)N=C1
InChI Code
InChI=1S/C22H24N8OS/c1-2-16-11-23-22(24-12-16)29-9-7-17(8-10-29)21-26-18(14-32-21)13-31-20-5-3-19(4-6-20)30-15-25-27-28-30/h3-6,11-12,14-15,17H,2,7-10,13H2,1H3
InChI Key
NFTMKHWBOINJGM-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Yang, J.W., Kim, H.S., Im, J.H., et al. GPR119: A promising target for nonalcoholic fatty liver disease FASEB J. 30(1), 324-335 (2016).

2. Lan, H., Lin, H.V., Wang, C.F., et al. Agonists at GPR119 mediate secretion of GLP-1 from mouse enteroendocrine cells through glucose-independent pathways Br. J. Pharmacol. 165(8), 2799-2807 (2012).

3. Spasov, A.A., Kosolapov, V.A., Babkov, D.A., et al. Effect of GRP119 receptor agonist, compound MBX-2982, on activity of human glucokinase Bull. Exp. Biol. Med. 163(5), 695-698 (2017).

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