We collect cookies for vital website function and to better serve our customers. By continuing to browse you agree to the storing of cookies on your device. See our privacy policy for details.

4'-O-methyl Quercetin

Item № 22406
CAS № 603-61-2
Purity ≥98%
product image
                (CAS 603-61-2)
     500 µg $49.00 0.00
     1 mg $93.00 0.00
     5 mg $368.00 0.00
     10 mg $686.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

  • 4'-methoxy Quercetin
  • Tamarixetin

4'-O-methyl Quercetin is a flavonoid isolated from C. ordata with anticancer and antiplasmodial activity. 4'-O-methyl Quercetin is a major metabolite of quercetin (Item No. 10005169) that inhibits the viability of HL-60, U937, MOLT-3, Raji, K562, MCF-7, SK-MEL-1, and A549 human tumor cell lines with IC50 values ranging from 5.5-24.1 μM.1 It induces G2-M arrest and inhibits tubulin polymerization in vitro in a dose-dependent manner. 4'-O-methyl Quercetin inhibits breast cancer resistance protein (BCRP/ABCG2; IC50 = 40 nM in a vesicular transport assay) with no cellular toxicity indicating potential for use in overcoming multidrug resistance in chemotherapy.2 4'-O-methyl Quercetin also reduces in vitro proliferation of chloroquine-resistant P. falciparum (IC50 = 4.8 μM) and suppresses infection in mice (65-81% suppression at 2.5-5 mg/kg dose).3

Recommended Products

Related Products
View Related Product Categories
Technical Information
Formal Name
CAS Number
  • 4'-methoxy Quercetin
  • Tamarixetin
Molecular Formula
Formula Weight
A solid
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Wet ice in continental US; may vary elsewhere
≥ 2 years
Downloads & Resources
Product Downloads

Download Product Insert

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Nicolini, F., Burmistrova, O., Marrero, M.T., et al. Induction of G2/M phase arrest and apoptosis by the flavonoid tamarixetin on human leukemia cells mol. Carcinog. 53(12), 939-950 (2014).

2. Tan, K.W., Li, Y., Paxton, J.W., et al. Identification of novel dietary phytochemicals inhibiting the efflux transporter breast cancer resistance protein (BCRP/ABCG2) Food Chem. 138(4), 2267-2274 (2013).

3. Ezenyi, I.C., Salawu, O.A., Kulkarni, R., et al. Antiplasmodial activity-aided isolation and identification of quercetin-4'-methyl ether in Chromolaena odorata leaf fraction with high activity against chloroquine-resistant Plasmodium falciparum Parasitol Res. 113(12), 4415-4422 (2014).

Technical Support
Contact Us
  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Cayman Contract Services

We work with scientists to accelerate their research, drug discovery, and drug development needs through our expertise in the following areas:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

Toll Free: (800) 364-9897

(USA and Canada Only)

Fax: (734) 971-3640