An antagonist of muscarinic acetylcholine receptors
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Oxybutynin (hydrochloride)

Item No. 23825

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(diethylamino)-2-butyn-1-yl ester α-cyclohexyl-α-hydroxy-benzeneacetic acid, monohydrochloride
CAS Number
1508-65-2
Synonyms
  • MJ4309-1
Molecular Formula
C22H31NO3 • HCl
Formula Weight
394.0
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 0.2 mg/ml
λmax
202 nm
SMILES
OC(C1CCCCC1)(C(OCC#CCN(CC)CC)=O)C2=CC=CC=C2.Cl
InChi Code
InChI=1S/C22H31NO3.ClH/c1-3-23(4-2)17-11-12-18-26-21(24)22(25,19-13-7-5-8-14-19)20-15-9-6-10-16-20;/h5,7-8,13-14,20,25H,3-4,6,9-10,15-18H2,1-2H3;1H
InChi Key
SWIJYDAEGSIQPZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $81

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    5 g

    $231

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    10 g

    $388

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    25 g

    $789

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    Product Description

    Oxybutynin is an antagonist of muscarinic acetylcholine receptors (Kis = 5, 14.5, 3.7, 5.3, and 40 nM for human recombinant M1-5, respectively).1 It inhibits intracellular calcium mobilization induced by carbamoylcholine (carbachol; Item No. 14486) in bladder smooth muscle and submandibular gland cells isolated from cynomolgus monkeys (Kis = 2 and 1 nM, respectively).2 Oxybutynin inhibits volume-induced bladder contraction (VIBC) and oxotremorine-induced salivation (OIS) in rats (ID50s = 0.062 and 0.089 mg/kg, respectively).1 It also increases pupil diameter (PD) and locomotor activity (LMA; ED50s = 0.29 and 0.52 mg/kg, respectively) and decreases small intestinal transit (SIT; ID50 = 0.22 mg/kg) in rats. Formulations containing oxybutynin have been used in the treatment of overactive bladder.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McNamara, A., Pulido-Rios, M.T., Sweazey, S., et al. Pharmacological properties of TD-6301, a novel bladder selective muscarinic receptor antagonist. Eur. J. Pharmacol. 605(1-3), 145-152 (2009).

    2. Kobayashi, S., Ikeda, K., and Miyata, K. Comparison of in vitro selectivity profiles of solifenacin succinate (YM905) and current antimuscarinic drugs in bladder and salivary glands: A Ca2+ mobilization study in monkey cells. Life Sci. 74(7), 843-853 (2004).