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ND-630

Item № 23961
CAS № 1434635-54-7
Purity ≥98%
product image
                (CAS 1434635-54-7)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $299.00 0.00
     5 mg $972.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description

ND-630 is an allosteric inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits ACC1 and ACC2 activity (IC50s = 2.1 and 6.1 nM, respectively, for the human enzymes).1 It is selective for ACC over 101 enzymes, receptors, growth factors, transporters, and ion channels up to a concentration of 10 µM. ND-630 prevents dimerization of ACC by interacting within the phosphopeptide-acceptor and dimerization site. It reduces fatty acid synthesis (EC50s = 66 and 9 nM in 10% FBS and serum-free media, respectively) and increases fatty acid oxidation in HepG2 cells. ND-630 reduces hepatic steatosis in a rat model of diet-induced obesity and in Zucker diabetic rats. It also improves insulin secretion stimulated by glucose and reduces hemoglobin A1c levels by 0.9% in Zucker diabetic rats.

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Technical Information
Formal Name
1,4-dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxo-thieno[2,3-d]pyrimidine-3(2H)-acetic acid
CAS Number
1434635-54-7
Molecular Formula
C28H31N3O8S
Formula Weight
569.6
Purity
≥98%
Formulation
A crystalline solid
λmax
205, 244, 312 nm
SMILES
O=C(C(C(C)=C(C1=NC=CO1)S2)=C2N3C[C@@H](C4=C(OC)C=CC=C4)OC5CCOCC5)N(C(C)(C)C(O)=O)C3=O
InChI Code
InChI=1S/C28H31N3O8S/c1-16-21-24(32)31(28(2,3)26(33)34)27(35)30(25(21)40-22(16)23-29-11-14-38-23)15-20(39-17-9-12-37-13-10-17)18-7-5-6-8-19(18)36-4/h5-8,11,14,17,20H,9-10,12-13,15H2,1-4H3,(H,33,34)/t20-/m0/s1
InChI Key
ZZWWXIBKLBMSCS-FQEVSTJZSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Harriman, G., Greenwood, J., Bhat, S., et al. Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats Proc. Natl. Acad. Sci. U.S.A. 113(13), E1796-1805 (2016).

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