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Galanin (rat, mouse) (trifluoroacetate salt)

Item № 24456
Purity ≥95%
product image
     1 mg $145.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

  • GAL (rat, mouse)
  • Galanin (1-29) (rat, mouse)

Galanin is a neuropeptide with diverse biological activities.1,2,3,4,5 It binds to rat galanin (GAL) receptor subtypes GAL1-3 (IC50s = 0.339, 1.35, and 3.31 nM, respectively) and human GAL1-3 (IC50s = 0.288, 1.62, and 12.3 nM, respectively).1 Galanin binds to and inhibits contraction of guinea pig gastric smooth muscle cells induced by carbachol (Item No. 14486; IC50s = 4 and 7.9 nM, respectively).2 In vivo, Galanin (6 nmol, i.c.v.) increases feeding behavior in rats and increases latency to hindpaw withdrawal in response to heat and mechanical stimulation in a rat model of carrageenin-induced inflammation when administered at a dose of 2 nmol injected into the nucleus accumbens.3,4 Galanin (5 μg, i.c.v.) also inhibits acetylcholine (Item No. 23829) release induced by scopolamine in the ventral hippocampus of freely moving rats.5

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Technical Information
Formal Name
glycyl-L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-L-leucylglycyl-L-prolyl-L-histidyl-L-alanyl-L-isoleucyl-L-α-aspartyl-L-asparaginyl-L-histidyl-L-arginyl-L-seryl-L-phenylalanyl-L-seryl-L-α-aspartyl-L-lysyl-L-histidylglycyl-L-leucyl-L-threoninamide, 2,2,2-trifluoroacetate
  • GAL (rat, mouse)
  • Galanin (1-29) (rat, mouse)
Molecular Formula
C141H211N43O41 • XCF3COOH
Formula Weight
A lyophilized powder
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Room temperature in continental US; may vary elsewhere
≥ 2 years
Downloads & Resources
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Branchek, T.A., Smith, K.E., Gerald, C., et al. Galanin receptor subtypes Trends Pharamacol. Sci. 21(3), 109-117 (2000).

2. Gu, Z.F., Pradhan, T.K., Coy, D.H., et al. Interaction of galanin fragments with galanin receptors on isolated smooth muscle cells from guinea pig stomach: Identification of a novel galanin receptor subtype J. Pharmacol. Exp. Ther. 272(1), 371-378 (1995).

3. Crawley, J.N., Austin, M.C., Fiske, S.M., et al. Activity of centrally administered galanin fragments on stimulation of feeding behavior and on galanin receptor binding in the rat hypothalamus J. Neurosci. 10(11), 3695-3700 (1990).

4. Yang, Y., Zhang, Y., Li, X.H., et al. Involvements of galanin and its receptors in antinociception in nucleus accumbens of rats with inflammatory pain Neurosci. Res. 97, 20-25 (2015).

5. Taber, M.T., and Crawley, J.N. Galanin attenuates the effects of scopolamine but not exposure to a novel environment on acetylcholine release in the rat ventral hippocampus Psychobiol. 27(1), 57-62 (1999).

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