We collect cookies for vital website function and to better serve our customers. By continuing to browse you agree to the storing of cookies on your device. See our privacy policy for details.

Galanin (rat, mouse) (trifluoroacetate salt)

Item № 24456
Purity ≥95%
product image
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $145.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

Description
Synonyms
  • GAL (rat, mouse)
  • Galanin (1-29) (rat, mouse)

Galanin is a neuropeptide with diverse biological activities.1,2,3,4,5 It binds to rat galanin (GAL) receptor subtypes GAL1-3 (IC50s = 0.339, 1.35, and 3.31 nM, respectively) and human GAL1-3 (IC50s = 0.288, 1.62, and 12.3 nM, respectively).1 Galanin binds to and inhibits contraction of guinea pig gastric smooth muscle cells induced by carbachol (Item No. 14486; IC50s = 4 and 7.9 nM, respectively).2 In vivo, Galanin (6 nmol, i.c.v.) increases feeding behavior in rats and increases latency to hindpaw withdrawal in response to heat and mechanical stimulation in a rat model of carrageenin-induced inflammation when administered at a dose of 2 nmol injected into the nucleus accumbens.3,4 Galanin (5 μg, i.c.v.) also inhibits acetylcholine (Item No. 23829) release induced by scopolamine in the ventral hippocampus of freely moving rats.5

Recommended Products

Related Products
View Related Product Categories
Technical Information
Formal Name
glycyl-L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-L-leucylglycyl-L-prolyl-L-histidyl-L-alanyl-L-isoleucyl-L-α-aspartyl-L-asparaginyl-L-histidyl-L-arginyl-L-seryl-L-phenylalanyl-L-seryl-L-α-aspartyl-L-lysyl-L-histidylglycyl-L-leucyl-L-threoninamide, 2,2,2-trifluoroacetate
Synonyms
  • GAL (rat, mouse)
  • Galanin (1-29) (rat, mouse)
Molecular Formula
C141H211N43O41 • XCF3COOH
Formula Weight
3164.4
Purity
≥95%
Formulation
A lyophilized powder
SMILES
NC([C@@]([C@@H](C)O)([H])NC([C@H](CC(C)C)NC(CNC([C@@H](NC([C@H](CCCCN)NC([C@@H](NC([C@H](CO)NC([C@@H](NC([C@H](CO)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CC(N)=O)NC([C@@H](NC([C@@]([C@H](CC)C)([H])NC([C@@H](NC([C@@H](NC([C@@H]1CCCN1C(CNC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@@H](NC(CNC([C@@H](NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC(CN[H])=O)CC2=CNC3=C2C=CC=C3)=O)=O)=O)=O)=O)C)=O)=O)CC4=CC=C(O)C=C4)=O)=O)=O)=O)=O)CC5=CN=CN5)=O)C)=O)=O)CC(O)=O)=O)=O)CC6=CN=CN6)=O)=O)=O)CC7=CC=CC=C7)=O)=O)CC(O)=O)=O)=O)CC8=CN=CN8)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChI Code
InChI=1S/C141H211N43O41.C2HF3O2/c1-15-71(10)113(139(224)177-100(52-112(199)200)132(217)173-97(49-105(144)191)129(214)171-96(48-81-57-151-66-159-81)128(213)166-86(30-23-37-152-141(147)148)122(207)178-102(62-186)136(221)169-92(43-76-25-17-16-18-26-76)127(212)180-103(63-187)137(222)174-99(51-111(197)198)131(216)165-85(29-21-22-36-142)121(206)170-94(46-79-55-149-64-157-79)120(205)155-59-109(195)163-88(40-68(4)5)133(218)182-114(74(13)188)116(146)201)181-118(203)73(12)161-123(208)95(47-80-56-150-65-158-80)175-138(223)104-31-24-38-184(104)110(196)60-156-119(204)87(39-67(2)3)167-124(209)89(41-69(6)7)168-126(211)91(44-77-32-34-82(190)35-33-77)164-108(194)58-154-117(202)72(11)160-135(220)101(61-185)179-130(215)98(50-106(145)192)172-125(210)90(42-70(8)9)176-140(225)115(75(14)189)183-134(219)93(162-107(193)53-143)45-78-54-153-84-28-20-19-27-83(78)84;3-2(4,5)1(6)7/h16-20,25-28,32-35,54-57,64-75,85-104,113-115,153,185-190H,15,21-24,29-31,36-53,58-63,142-143H2,1-14H3,(H2,144,191)(H2,145,192)(H2,146,201)(H,149,157)(H,150,158)(H,151,159)(H,154,202)(H,155,205)(H,156,204)(H,160,220)(H,161,208)(H,162,193)(H,163,195)(H,164,194)(H,165,216)(H,166,213)(H,167,209)(H,168,211)(H,169,221)(H,170,206)(H,171,214)(H,172,210)(H,173,217)(H,174,222)(H,175,223)(H,176,225)(H,177,224)(H,178,207)(H,179,215)(H,180,212)(H,181,203)(H,182,218)(H,183,219)(H,197,198)(H,199,200)(H4,147,148,152);(H,6,7)/t71-,72-,73-,74+,75+,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,113-,114-,115-;/m0./s1
InChI Key
FLJGXSBWVFANHA-DKFOPZTRSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
Product Downloads

Download Product Insert

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Branchek, T.A., Smith, K.E., Gerald, C., et al. Galanin receptor subtypes Trends Pharamacol. Sci. 21(3), 109-117 (2000).

2. Gu, Z.F., Pradhan, T.K., Coy, D.H., et al. Interaction of galanin fragments with galanin receptors on isolated smooth muscle cells from guinea pig stomach: Identification of a novel galanin receptor subtype J. Pharmacol. Exp. Ther. 272(1), 371-378 (1995).

3. Crawley, J.N., Austin, M.C., Fiske, S.M., et al. Activity of centrally administered galanin fragments on stimulation of feeding behavior and on galanin receptor binding in the rat hypothalamus J. Neurosci. 10(11), 3695-3700 (1990).

4. Yang, Y., Zhang, Y., Li, X.H., et al. Involvements of galanin and its receptors in antinociception in nucleus accumbens of rats with inflammatory pain Neurosci. Res. 97, 20-25 (2015).

5. Taber, M.T., and Crawley, J.N. Galanin attenuates the effects of scopolamine but not exposure to a novel environment on acetylcholine release in the rat ventral hippocampus Psychobiol. 27(1), 57-62 (1999).

Technical Support
Contact Us
  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Cayman Contract Services

We work with scientists to accelerate their research, drug discovery, and drug development needs through our expertise in the following areas:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

Toll Free: (800) 364-9897

(USA and Canada Only)

Fax: (734) 971-3640