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Gastrin I (human)

Item № 24457
CAS № 10047-33-3
Purity ≥95%
product image
                (CAS 10047-33-3)
     1 mg $225.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

  • Gastrin I (1-17) (human)
  • Gastrin Heptadecapeptide I (human)

Gastrin I is an endogenous, gastrointestinal peptide hormone that binds to cholecystokinin (CCK) receptors on human gastric leiomyosarcoma cells (IC50 = 0.9 nM) and in guinea pig gallbladder and pancreatic tissue (IC50s = 1.7 and 2.5 μM, respectively).1,2 It increases levels of cytosolic calcium in isolated rabbit stomach parietal cells (EC50 = 11 nM) and stimulates pepsinogen secretion by isolated human peptic cells (ED50 = 30 nM).3,4 Gastrin I increases histidine decarboxylase (HDC) activity ex vivo in fundic stomach mucosa homogenate and increases gastric acid secretion in vivo in rats when administered at a dose of 1 nmol/kg/h.5

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Technical Information
Formal Name
CAS Number
  • Gastrin I (1-17) (human)
  • Gastrin Heptadecapeptide I (human)
Molecular Formula
Formula Weight
A lyophilized powder
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Room temperature in continental US; may vary elsewhere
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Miller, L.J. Characterization of cholecystokinin receptors on human gastric smooth muscle tumors Am. J. Physiol. 247(4 Pt 1), G402-G410 (1984).

2. von Schrenck, T., Moran, T.H., Heinz-Erian, P., et al. Cholecystokinin receptors on gallbladder muscle and pancreatic acinar cells: A comparative study Am. J. Physiol. 255(4 Pt 1), G512-G521 (1988).

3. Letari, O., Mennuni, L., Colombo, S., et al. Cytosolic Ca2+ evaluation in rabbit parietal cells: A novel method to screen gastrin receptor antagonists Eur. J. Pharmacol. 306(1-3), 325-333 (1996).

4. Lanas, A.I., Anderson, J.W., Uemura, N., et al. Effects of cholinergic, histaminergic, and peptidergic stimulation on pepsinogen secretion by isolated human peptic cells Scand. J. Gastroenterol. 29(8), 678-683 (1994).

5. Kawabata, S., Kanayama, S., Shinomura, Y., et al. Effect of cholecystokinin receptor antagonists, MK-329 and L-365,260, on cholecystokinin-induced acid secretion and histidine decarboxylase activity in the rat Regul. Pept. 35(1), 1-10 (1991).

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