Pricing updated 2019-07-23. Prices are subject to change without notice.
Gastrin I is an endogenous, gastrointestinal peptide hormone that binds to cholecystokinin (CCK) receptors on human gastric leiomyosarcoma cells (IC50 = 0.9 nM) and in guinea pig gallbladder and pancreatic tissue (IC50s = 1.7 and 2.5 μM, respectively).1,2 It increases levels of cytosolic calcium in isolated rabbit stomach parietal cells (EC50 = 11 nM) and stimulates pepsinogen secretion by isolated human peptic cells (ED50 = 30 nM).3,4 Gastrin I increases histidine decarboxylase (HDC) activity ex vivo in fundic stomach mucosa homogenate and increases gastric acid secretion in vivo in rats when administered at a dose of 1 nmol/kg/h.5
Warning - this product is not for human or veterinary use.
View the Cayman Structure Database for chemical structure definitions for many Cayman products
Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.
1. Miller, L.J. Characterization of cholecystokinin receptors on human gastric smooth muscle tumors Am. J. Physiol. 247(4 Pt 1), G402-G410 (1984).
von Schrenck, T., Moran, T.H., Heinz-
3. Letari, O., Mennuni, L., Colombo, S., et al. Cytosolic Ca2+ evaluation in rabbit parietal cells: A novel method to screen gastrin receptor antagonists Eur. J. Pharmacol. 306(1-3), 325-333 (1996).
4. Lanas, A.I., Anderson, J.W., Uemura, N., et al. Effects of cholinergic, histaminergic, and peptidergic stimulation on pepsinogen secretion by isolated human peptic cells Scand. J. Gastroenterol. 29(8), 678-683 (1994).
Kawabata, S., Kanayama, S., Shinomura, Y., et al. Effect of cholecystokinin receptor antagonists, MK-