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(+)-Cedrol

Item № 25769
CAS № 77-53-2
Purity ≥98%
product image
                (CAS 77-53-2)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     100 mg $55.00 0.00
     250 mg $124.00 0.00

Pricing updated 2019-07-18. Prices are subject to change without notice.

Description
Synonyms
  • α-Cedrol

(+)-Cedrol is a sesquiterpene alcohol that has been used in Cannabis testing and has diverse biological activities.1 It inhibits the growth of L. sulphureus, G. trabeum, L. betulina, and T. versicolor wood decay fungi when used at a concentration of 100 μg/ml.2 (+)-Cedrol inhibits the cytochrome P450 (CYP) isoforms CYP2B6 and CYP3A4 (Kis = 0.9 and 3.4 μM, respectively).3 In vivo, (+)-cedrol (200 mg/kg) prevents hair follicle dystrophy and reduces hair loss in a mouse model of alopecia induced by cyclophosphamide (Item No. 13849).4 (+)-Cedrol-loaded nanostructured lipid particles reduce peritoneal mast cell degranulation, a component of the type I anaphylactic response, induced by compound 48/80 (Item No. 22173) in mice.5

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Technical Information
Formal Name
(3R,3aS,6R,7R,8aS)-octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-6-ol
CAS Number
77-53-2
Synonyms
  • α-Cedrol
Molecular Formula
C15H26O
Formula Weight
222.4
Purity
≥98%
Formulation
A solid
SMILES
CC([C@]1([H])[C@](C)(O)CC2)(C)[C@@]3([H])[C@@]2(C1)[C@H](C)CC3
InChI Code
InChI=1S/C15H26O/c1-10-5-6-11-13(2,3)12-9-15(10,11)8-7-14(12,4)16/h10-12,16H,5-9H2,1-4H3/t10-,11+,12-,14-,15+/m1/s1
InChI Key
SVURIXNDRWRAFU-OGMFBOKVSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Fischedick, J.T. Identification of terpenoid chemotypes among high (–)-trans-Δ9-tetrahydrocannabinol-producing Cannabis sativa L. cultivars Cannabis Cannabinoid Res. 2(1), 34-47 (2017).

2. Cheng, S.S., Chung, M.J., Lin, C.Y., et al. Phytochemicals from Cunninghamia konishii Hayata act as antifungal agents J. Agric. Food Chem. 60(1), 124-128 (2012).

3. Jeong, H.U., Kwon, S.S., Kong, T.Y., et al. Inhibitory effects of cedrol, β-cedrene, and thujopsene on cytochrome P450 enzyme activities in human liver microsomes J. Toxicol. Environ. Health A. 77(22-24), 1522-1532 (2014).

4. Chen, S.S., Zhang, Y., Lu, Q.L., et al. Preventive effects of cedrol against alopecia in cyclophosphamide-treated mice Environ. Toxicol. Pharmacol. 46, 270-276 (2016).

5. Chakraborty, S., Kar, N., Kumari, L., et al. Inhibitory effect of a new orally active cedrol-loaded nanostructured lipid carrier on compound 48/80-induced mast cell degranulation and anaphylactic shock in mice Int. J. Nanomedicine 12, 4849-4868 (2017).

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