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T-863

Item № 25807
CAS № 701232-20-4
Purity ≥95%
product image
                (CAS 701232-20-4)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $29.00 0.00
     5 mg $102.00 0.00
     10 mg $189.00 0.00
     25 mg $399.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

Description

T-863 is a potent inhibitor of diacylglycerol acetyltransferase-1 (DGAT-1; IC50 = 15 nM).1 It is selective for DGAT-1 over DGAT-2 and acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1; IC50s = >10 and 12 μM, respectively). T-863 inhibits triacylglycerol synthesis in HuTu 80 cells (IC50 = 4 nM). In vivo, T-863 (20 mg/kg) reduces plasma triacylglycerol levels, the ratio of triacylglycerols to diacylglycerols, and body weight in a mouse model of diet-induced obesity.

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Technical Information
Formal Name
trans-4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]-cyclohexaneacetic acid
CAS Number
701232-20-4
Molecular Formula
C22H26N4O3
Formula Weight
394.5
Purity
≥95%
Formulation
A crystalline solid
λmax
238, 335 nm
SMILES
OC(C[C@@H]1CC[C@@H](C2=CC=C(C3=NC(C(N)=NC=N4)=C4OC3(C)C)C=C2)CC1)=O
InChI Code
InChI=1S/C22H26N4O3/c1-22(2)19(26-18-20(23)24-12-25-21(18)29-22)16-9-7-15(8-10-16)14-5-3-13(4-6-14)11-17(27)28/h7-10,12-14H,3-6,11H2,1-2H3,(H,27,28)(H2,23,24,25)/t13-,14-
InChI Key
FUIYMYNYUHVDPT-HDJSIYSDSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Birch, A.M., Birtles, S., Buckett, L.K., et al. Discovery of a potent, selective, and orally efficacious pyrimidinooxazinyl bicyclooctaneacetic acid diacylglycerol acyltransferase-1 inhibitor J. Med. Chem. 52(6), 1558-1568 (2009).

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