An inhibitor of HMG-CoA reductase
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Simvastatin Hydroxy Acid (ammonium salt)

Item No. 34883

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(βR,δR,1S,2S,6R,8S,8aR)-8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-1-naphthaleneheptanoic acid, monoammonium salt
CAS Number
139893-43-9
Synonyms
  • SVA Hydroxy Acid
Molecular Formula
C25H39O6 • NH4
Formula Weight
453.6
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
231, 238, 247 nm
SMILES
CCC(C)(C)C(O[C@@H]1[C@@]2([H])C(C=C[C@@H]([C@@H]2CC[C@@H](O)C[C@@H](O)CC([O-])=O)C)=C[C@@H](C1)C)=O.[NH4+]
InChi Code
InChI=1S/C25H40O6.H3N/c1-6-25(4,5)24(30)31-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-18(26)13-19(27)14-22(28)29;/h7-8,11,15-16,18-21,23,26-27H,6,9-10,12-14H2,1-5H3,(H,28,29);1H3/t15-,16-,18+,19+,20-,21-,23-;/m0./s1
InChi Key
FFPDWNBTEIXJJF-OKDJMAGBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $54

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    10 mg

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    25 mg

    $172

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    50 mg

    $262

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Simvastatin hydroxy acid is an inhibitor of HMG-CoA reductase (Ki = 0.12 nM) and an active metabolite of simvastatin (Item Nos. 10010344 | 10010345).1 It is formed from simvastatin via hydrolysis and nonspecific esterases.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Corsini, A., Maggi, F.M., and Catapano, A.L. Pharmacology of competitive inhibitors of HMG-CoA reductase. Pharmacol. Res. 31(1), 9-27 (1995).

    2. Vickers, S., Duncan, C.A., Vyas, K.P., et al. In vitro and in vivo biotransformation of simvastatin, an inhibitor of HMG CoA reductase. Drug Metab. Dispos. 18(4), 476-483 (1990).