A degrader of ERα
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Estrogen Receptor Antagonist 2

Item No. 43587

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[1-(3-fluoropropyl)-3-azetidinyl]-6-[(6S,8R)-6,7,8,9-tetrahydro-8-methyl-7-(2,2,2-trifluoroethyl)-3H-pyrazolo[4,3-f]isoquinolin-6-yl]-3-pyridinamine
CAS Number
2222844-89-3
Synonyms
  • AZD9833
Molecular Formula
C24H28F4N6
Formula Weight
476.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/mlEthanol: Soluble: ≥ 10 mg/ml
SMILES
FCCCN(C1)CC1NC2=CC=C([C@@H]3C(C=CC4=C5C=NN4)=C5C[C@H](N3CC(F)(F)F)C)N=C2
InChi Code
InChI=1S/C24H28F4N6/c1-15-9-19-18(4-6-21-20(19)11-30-32-21)23(34(15)14-24(26,27)28)22-5-3-16(10-29-22)31-17-12-33(13-17)8-2-7-25/h3-6,10-11,15,17,23,31H,2,7-9,12-14H2,1H3,(H,30,32)/t15-,23+/m1/s1
InChi Key
WDHOIABIERMLGY-CMJOXMDJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $275

    Add

    10 mg

    $523

    Add

    25 mg

    $1,238

    Add

    50 mg

    $1,513

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Estrogen receptor antagonist 2 is a degrader of estrogen receptor α (ERα).1 It induces degradation of ERα in MCF-7 breast cancer cells (IC50 = 0.16 nM). Estrogen receptor antagonist 2 inhibits estradiol-induced growth in MCF-7 cells (IC50 = 5.01 nM). In vivo, estrogen receptor antagonist 2 (0.5-50 mg/kg per day) decreases tumor volume in an MCF-7 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Scott, J.S., Moss, T.A., Balazs, A., et al. Discovery of AZD9833, a potent and orally bioavailable selective estrogen receptor degrader and antagonist. J. Med. Chem. 63(23), 14530-14559 (2020).