Glyco-SPOT DNA Repair Assay Kit | Cayman Chemical
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Glyco-SPOT DNA Repair Assay Kit

Item № 501280
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     24 dtn $1,374.00 0.00

Pricing updated 2018-11-16. Prices are subject to change without notice.

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Description
Features
  • Profile glycosylase/AP endonuclease activities
  • Sample Types: Pure Enzyme | Cell Nuclear Extracts | Whole Cell Extracts | Tissue Extracts
  • HTS friendly, fluorescent microarray
  • Species Compatibility: Human | Mouse | Rat | Fish | Bacteria

Base Excision Repair (BER) is the predominant repair pathway responsible for removal of small lesions from DNA, like oxidized, alkylated, deaminated bases and abasic sites. In humans, the mechanism of BER involves the initial action of DNA glycosylases followed by the processing of the resulting abasic site either by the AP-lyase activity of the bifunctional glycosylase or by the apurinic/apyrimiddic endonuclease APE1 that incises the DNA strand. BER mechanisms can be induced by oxidative stress and various genotoxic attacks. The Glyco-SPOT DNA Repair Assay is a multiplexed oligonucleotide cleavage assay developed on support. It is used to monitor simultaneously the cleavage efficiency of several glycosylases/AP endonucleases against a set of emblematic DNA lesions in cell/bacteria/tissue extracts, using fluorescent detection. The assay can be used to screen for DNA repair inhibitors, characterize DNA repair enzymatic signature from samples, check DNA glycosylase specificity, and characterize DNA repair inhibitory properties of chemicals (heavy metals …). [Bertin Catalog No. LX05001]

Needed but not supplied: Please download the kit booklet to verify if UltraPure Water (Milli-Q or equivalent) or any other components are needed for this assay.

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Technical Information
Specificity
  • (+) Human
  • (+) Bacteria
  • (+) Fish
Show all 5

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
4°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 6 months
Downloads & Resources
Product Downloads

Download Kit Booklet

Download free InChI Key generation software

Additional Information

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Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

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You may be eligible to receive a free sample of Glyco-SPOT DNA Repair Assay Kit under the Cayman Challenge program.

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

Toll Free: (800) 364-9897

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