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Estrone-3-Glucuronide ELISA Kit

Item № 501290
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     96 solid plate $245.00 0.00
     96 strip plate $245.00 0.00

Pricing updated 2019-03-26. Prices are subject to change without notice.

Description
Features
  • Measures estrone-3-glucuronide, the predominant metabolite of estradiol in biological matrices
  • Assay 24 samples in triplicate or 36 samples in duplicate
  • Lower limit of detection (LLOD) is 6.6 pg/ml
  • Rapid 2-hour or overnight incubation options
Synonyms
  • Estrone-3-Glucuronide EIA Kit
  • E1G

Estrone-3-glucuronide is the predominant metabolite of estradiol in urine and a urinary marker for the fertile window in women.1 Measurement of urinary glucuronides is a convenient, non-invasive method for detecting reproductive hormone levels compared to measuring plasma levels.2 Estrone-3-glucuronide, along with pregnanediol-3-glucuronide, are indicators of female reproductive health.2

Literature has shown high serum estrone levels, which directly correlate to urinary estrone-3-glucuronide levels, are associated with estrogen receptor-positive breast cancers.3 Hormone receptor status is the main factor in planning treatment and can be treated with hormone therapies, including tamoxifen and aromatase inhibitors.4 In addition to its role in breast cancer, circulating estrogens, including estrone metabolized from oral hormone replacement therapy, have been shown to increase thrombin generation leading to higher risk for blood clots, myocardial infarctions, deep vein thrombosis and strokes.5,6

Needed but not supplied: Please download the kit booklet to verify if UltraPure Water (Milli-Q or equivalent) or any other components are needed for this assay.

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Technical Information
Synonyms
  • Estrone-3-Glucuronide EIA Kit
  • E1G
Limit of Detection
6.6 pg/ml (overnight); 10.1 pg/ml (rapid)
Assay Range
2.7-6,000 pg/ml
Sensitivity
23.2 pg/ml (overnight); 36.1 pg/ml (rapid)
Mid-point
125.6 pg/ml (overnight); 246.8 pg/ml (rapid)
Cross Reactivity
  • (100%) Estrone-3-Glucuronide
  • (133%) Estrone Sulfate
  • (0.1%) Estradiol Sulfate
Show all 12
Origin
  • Animal/Bovine
  • Animal/Rabbit

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 1 year
Downloads & Resources
Product Downloads

Download Kit Booklet

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Eichner, S.F., and Timpe, E.M. Urinary-based ovulation and pregnancy: Point-of-care testing Ann. Pharmacother. 38(2), 325-331 (2004).

2. O'Connor, K.A., Brindle, E., Holman, D.J., et al. Urinary estrone conjugate and pregnanediol 3-glucuronide enzyme immunoassays for population research Clin. Chem. 49(7), 1139-1148 (2003).

3. Miyoshi, Y., Tanji, Y., Taguchi, T., et al. Association of serum estrone levels with estrogen receptor-positive breast cancer risk in postmenopausal Japanese women Clin. Cancer Res. 9(6), 2229-2233 (2003).

4. Bagot, C.N., Marsh, M.S., Whitehead, M.I., et al. The effect of estrone on thrombin generation may explain the different thrombotic risk between oral and transdermal hormone replacement therapyexa J. Thromb. Haemost. 8(8), 1736-1744 (2010).

5. Karim, R.M., Mack, W.J., Hodis, H.N., et al. Influence of age and obesity on serum estradiol, estrone, and sex hormone binding globulin concentrations following oral estrogen administration in postmenopausal women J. Clin. Endocrinol. Metab. 94(11), 4136-4143 (2009).

6. Dong, M., Mu, N., Ren, F., et al. Prospective study of effects of endogenous estrogens on myocardial no-reflow risk in postmenopausal women with acute myocardial infarction J. Interv. Cardiol. 27(5), 437-443 (2014).

Technical Support
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