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Pregnanediol-3-Glucuronide (PDG) ELISA Kit

Item № 501300
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     96 solid wells $245.00 0.00
     96 strip wells $245.00 0.00

Pricing updated 2019-05-25. Prices are subject to change without notice.

Description
Features
  • Measures pregnanediol-3-glucuronide, the primary urinary metabolite of progesterone
  • Assay 24 samples in triplicate or 36 samples in duplicate
  • Measure pregnanediol-3-glucuronide levels down to 0.23 ng/ml
  • Incubation: 2 hours | Development: 60 minutes | Read: Colorimetric at 405 nm
Synonyms
  • PDG
  • Pregnanediol-3-Glucuronide (PDG) EIA Kit

Pregnanediol-3-Glucuronide (5β-pregnane-3α,20α-diol-3α-glucuronide, PDG or P3G) is the major metabolite of progesterone, an endogenous steroid and the most important member of the class of steroid hormones known as progestogens. Progesterone is important in a variety of biological functions such as preparing the endometrium for implantation, maintaining pregnancy, differentiating breast tissue, and promoting normal development of neurons in the brain as a neuro steroid. Low progesterone levels are linked to chronic anovulation which is reported to be associated with female infertility, breast cancer and endometrial cancer.1,2 Levels of PDG in the urine correlate highly to levels of progesterone measured in the serum.3,4 PDG analysis may be used as a non-invasive method to indirectly measure progesterone and therefore might be used as a biomarker for luteal activity, ovarian cancer, and a variety of other biological disorders.5,6,7

Needed but not supplied: Please download the kit booklet to verify if UltraPure Water (Milli-Q or equivalent) or any other components are needed for this assay.

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Technical Information
Synonyms
  • PDG
  • Pregnanediol-3-Glucuronide (PDG) EIA Kit
Limit of Detection
0.23 ng/ml
Assay Range
0.4-50 ng/ml
Sensitivity
0.94 ng/ml
Mid-point
4.30 ng/ml
Cross Reactivity
  • (0.009%) Cortisol
  • (100%) Pregnanediol-3-Glucuronide
  • (25.8%) Progesterone
Show all 10
Origin
  • Animal/Bovine
  • Animal/Mouse
  • Animal/Rabbit

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 1 year
Downloads & Resources
Product Downloads

Download Kit Booklet

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Kassam, A., Overstreet, J.W., Snow-Harter, C., et al. Identification of anovulation and transient luteal function using a urinary pregnanediol-3-glucuronide ratio algorithm Environ. Health Perspect. 104(4), 408-413 (1996).

2. Wiebe, J.P. Progesterone metabolites in breast cancer Endocr. Relat. Cancer 13(3), 717-738 (2006).

3. O'Connor, K.A., Brindle, E., Holman, D.J., et al. Urinary estrone conjugate and pregnanediol 3-glucuronide enzyme immunoassays for population research Clin. Chem. 49(7), 1139-1148 (2003).

4. Munro, C.J., Stabenfeldt, G.H., Cragun, J.R., et al. Relationship of serum estradiol and progesterone concentrations to the excretion profiles of their major urinary metabolites as measured by enzyme immunoassay and radioimmunoassay Clin. Chem. 37(6), 838-844 (1991).

5. Pavlovic, J.M., Allshouse, A.A., Santoro, N.F., et al. Sex hormones in women with and without migraine: Evidence of migraine-specific hormone profiles Neurology 87(1), 49-56 (2016).

6. Lukanova, A., and Kaaks, R. Endogenous hormones and ovarian cancer: Epidemiology and current hypotheses Can. Epidemiol Biomarkers Prev. 14(1), 98-107 (2005).

7. Kim, J.J., Kurita, T., and Bulun, S.E. Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer Endocr. Rev. 34(1), 130-162 (2013).

Technical Support
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