|96 solid wells||$395.00||0.00|
|96 strip wells||$395.00||0.00|
Pricing updated 2019-05-25. Prices are subject to change without notice.
Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that detects the presence of nucleic acids in the cytosol of mammalian cells as an indicator of bacterial or viral infection.1 cGAS catalyzes the synthesis of a second messenger, 2’3’-cGAMP, from cytosolic ATP and GTP in response to dsDNA binding. 2’3’-cGAMP then binds tightly to the adaptor protein STING (stimulator of interferon genes), resulting in the recruitment of TBK1 and subsequent IRF3 phosphorylation.2 IRF3 induces the transcription and translation type I interferon, a potent antiviral cytokine.3 Activation of cGAS and the production of 2’3’-cGAMP are important in host defense, but also may play role in autoimmune or inflammatory diseases. Modulation of cGAS activity, with subsequent inhibition of induction of 2’3’-cGAMP formation is an active target of pharmacological intervention.4 Powered by BIOLOG Life Science Institute.
Warning - this product is not for human or veterinary use.
View the Cayman Structure Database for chemical structure definitions for many Cayman products
Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.
Sun, L., Wu, J., Du, F., et al. Cyclic GMP-
Hall, J., Brault, A., Vincent, F., et al. Discovery of PF-
3. O'Neill, L.A. Sensing the dark side of DNA Science 339(6121), 763-764 (2013).
Cai, X., Chiu, Y.-