|96 solid wells||$425.00||0.00|
|96 strip wells||$425.00||0.00|
Pricing updated 2018-07-16. Prices are subject to change without notice.
Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that detects the presence of nucleic acids in the cytosol of mammalian cells as an indicator of bacterial or viral infection.1 cGAS catalyzes the synthesis of a second messenger, 2’3’-cGAMP, from cytosolic ATP and GTP in response to dsDNA binding. 2’3’-cGAMP then binds tightly to the adaptor protein STING (stimulator of interferon genes), resulting in the recruitment of TBK1 and subsequent IRF3 phosphorylation.2 IRF3 induces the transcription and translation type I interferon, a potent antiviral cytokine.3 Activation of cGAS and the production of 2’3’-cGAMP are important in host defense, but also may play role in autoimmune or inflammatory diseases. Modulation of cGAS activity, with subsequent inhibition of induction of 2’3’-cGAMP formation is an active target of pharmacological intervention.4
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Sun, L., Wu, J., Du, F., et al. Cyclic GMP-
Hall, J., Brault, A., Vincent, F., et al. Discovery of PF-
3. O'Neill, L.A. Sensing the dark side of DNA. Science 339(6121), 763-764 (2013).
Cai, X., Chiu, Y.-