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Protein methionine sulfoxide (MetO) is a reversible oxidative modification that occurs by exposure of protein(s) methionine residues to reactive oxygen species (ROS).1,2 Methionine oxidation can alter the function(s) of the modified proteins and if not reversed by MetO reductases can be further oxidized to methionine sulfone, an irreversible modification.3 Methionine oxidation may occur as a by-
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1. Stadtman, E.R.,Van Remmen, H.,Richardson, A., et al. Methionine oxidation and aging. Biochimica et Biophysica Acta 1703, 135-140 (2005).
Oien, D.B.,Canello, T.,Gabizon, R., et al. Detection of oxidized methionine in selected proteins, cellular extracts and blood serums by novel anti-
Moskovitz, J.,Jenkins, N.A.,Gilbert, D.J., et al. Chromosomal localization of the mammalian peptide-
4. Berlett, B.S. and Stadtman, E.R. Protein oxidation in aging, disease, and oxidative stress. The Journal of Biological Chemisty 272(33), 20313-20316 (1997).
Cabreiro, F.,Picot, C.R.,Perichon, M., et al. Overexpression of mitochondrial methionine sulfoxide reductase B2 protects leukemia cells from oxidative stress-
6. Levine, R.L.,Mosoni, L.,Berlett, B.S., et al. Methionine residues as endogenous antioxidants in proteins. Proceedings of the National Academy of Sciences of the United States of America 93, 15036-15040 (1996).