PAD4 Inhibitor Screening Assay Kit (Ammonia) | Cayman Chemical
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PAD4 Inhibitor Screening Assay Kit (Ammonia)

Item № 700560
product image
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     96 wells $425.00 0.00

Pricing updated 2018-08-15. Prices are subject to change without notice.

Description
Features
  • Screen for inhibitors of PAD4
  • Assay 45 samples in duplicate
  • Plate-based fluorometric measurement (ex 405-415 nm, em 470-480 nm)
  • Orthogonal assay to Cayman’s PAD4 Inhibitor Screening Assay Kit (AMC) (Item No. 701320)
Synonyms
  • PADI4
  • PADI5
  • PDI5
  • Peptidylarginine Deiminase 4
  • Protein Arginine Deiminase 4

Protein Arginine Deiminase 4 (PAD4) is a guanidino-modifying enzyme that functions as a transcriptional coregulator catalyzing the conversion of specific arginine residues to citrulline. Substrates for PAD4 include histones H2A, H3, and H4. PAD4 autocitrullinates itself at several sites, inhibiting its enzymatic activity. PAD4 activity is increased in rheumatoid arthritis, producing an abundance of citrulline-containing proteins that generate an immune response resulting in production of autoantibodies that ultimately attack the host tissues. PAD4 has also been implicated in several other diseases including multiple sclerosis, Alzheimer’s disease, glaucoma, and cancer. Cayman’s PAD4 Inhibitor Screening Assay (Ammonia) provides a convenient, fluorescence-based method for screening human PAD4 inhibitors.

Needed but not supplied: Please download the kit booklet to verify if UltraPure Water (Milli-Q or equivalent) or any other components are needed for this assay.

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Technical Information
Synonyms
  • PADI4
  • PADI5
  • PDI5
  • Peptidylarginine Deiminase 4
  • Protein Arginine Deiminase 4

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Stability
≥ 1 year
Downloads & Resources
Product Downloads

Download Kit Booklet

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

Technical Support
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  • Direct Phone: (734) 975-3888
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You may be eligible to receive a free sample of PAD4 Inhibitor Screening Assay Kit (Ammonia) under the Cayman Challenge program.

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

Toll Free: (800) 364-9897

(USA and Canada Only)

Fax: (734) 971-3640