|96 solid wells||$295.00||0.00|
|96 strip wells||$295.00||0.00|
Pricing updated 2019-02-20. Prices are subject to change without notice.
Δ9-Tetrahydrocannabinol (Δ9THC) is the primary psychoactive chemical that results from the consumption of Cannabis. Upon consumption, this cannabinoid (CB) acts as a partial agonist with both the central CB receptor 1 (CB1) and the peripheral CB receptor 2 (CB2).1,2 Its actions are analogous to the endogenous neurotransmitter anandamide when it binds to receptors and alters mental and physical functions in the body.3 Once in the liver, Δ9-THC gets broken down by cytochrome p450 enzymes CYP2C9, CYP2C19, CYP3A4, to the psychoactive metabolite 11-hydroxy-THC.4,5 11-hydroxy-THC is then further oxidized to the non-psychoactive metabolite 11-nor-9-carboxy-THC.6 This carboxy form has been found to be the most abundant metabolite of Δ9-Tetrahydrocannabinol. For this reason, it is often used as the main urinary marker for Cannabis consumption.
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Viñals, X., Moreno, E., Lanfumey, L., et al. Cognitive impairment induced by delta9-
2. Pertwee, R.G., Howlett, A.C., Abood, M.E., et al. International union of basic and clinical pharmacology. LXXIX. Cannabinoid receptors and their ligands: Beyond CB1 and CB2 Pharmacol. Rev. 62(4), 588-631 (2010).
Pertwee, R.G. The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-
4. Arellano, A.L., Papaseit, E., Romaguera, A., et al. Neuropsychiatric and general interactions of natural and synthetic cannabinoids with drugs of abuse and medicines CNS Neurol. Disord. Drug Target 16(5), 554-566 (2017).
5. Watanabe, K., Yamaori, S., Funahashi, T., et al. Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes Life Sci. 80(15), 1415-1419 (2007).
Schwilke, E.W., Schwope, D.M., Karschner, E.L., et al. Δ9-