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trans-Resveratrol

Item № 70675
CAS № 501-36-0
Purity ≥98%
product image
                (CAS 501-36-0)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     50 mg $19.00 0.00
     100 mg $36.00 0.00
     250 mg $86.00 0.00
     500 mg $114.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

Description
Synonyms
  • (E)-Resveratrol

trans-Resveratrol is a polyphenolic phytoalexin found in a variety of plants, including grapes, that has anti-inflammatory, antioxidant, and anticancer activities.1,2 It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 μM, respectively), but not COX-2 (EC50s = >100 μM and 85 μM, respectively).1 trans-Resveratrol (3 and 8 mg/kg) inhibits carrageenan-induced paw edema in mice. It inhibits free radical formation in HL-60 human promyelocytic leukemia cells induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014; EC50 = 27 μM). trans-Resveratrol (1-25 μmol) reduces both the incidence and number of tumors in a two-stage mouse model of skin cancer induced by TPA and 7,12-dimethyl-benz[a]anthracene (DMBA). trans-Resveratrol (200 μM) also activates sirtuin 1 (SIRT1) by 8-fold in vitro and inhibits a variety of targets including ERK1, JNK1, Src, PKCα, aromatase/CYP19, and DNA polymerases α and δ (IC50s = 37, 50, 20, <10, 25, 3.3, and 5 μM, respectively) in vitro and/or ex vivo.3,2 It prolongs lifespan in model organisms including C. elegan, D. melanogaster, and mice.2

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Technical Information
Formal Name
5-[(1E)-2-(4-hydroxyphenyl)ethenyl]-1,3-benzenediol
CAS Number
501-36-0
Synonyms
  • (E)-Resveratrol
Molecular Formula
C14H12O3
Formula Weight
228.2
Purity
≥98%
Formulation
A crystalline solid
λmax
218, 307, 321 nm
SMILES
Oc1ccc(cc1)\C=C/c1cc(O)cc(O)c1
InChI Code
InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+
InChI Key
LUKBXSAWLPMMSZ-OWOJBTEDSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

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References & Product Citations
Product Description References

1. Jang, M., Cai, L., Udeani, G.O., et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes Science 275, 218-220 (1997).

2. Pirola, L., and Fröjdö, S. Resveratrol: One molecule, many targets IUMBM Life 60(5), 323-332 (2008).

3. Borra, M.T., Smith, B.C., and Denu, J.M. Mechanism of human SIRT1 activation by resveratrol The Journal of Biological Chemisty 280(17), 17187-17195 (2005).

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