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Wy 14643

Item № 70730
CAS № 50892-23-4
Purity ≥98%
product image
                (CAS 50892-23-4)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 mg $9.00 0.00
     10 mg $17.00 0.00
     50 mg $72.00 0.00
     250 mg $270.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description
Synonyms
  • Pirinixic Acid

Wy 14643 is a peroxisome proliferator-activated receptor (PPAR activator). Although this compound is primarily an activator of PPARα,1,2,3 it activates PPARγ as well.4 Activation of PPARδ by Wy 14643 is also observed,5 but this finding is rare. The potency of Wy 14643 as an activator of PPARα is species dependent, with receptor activation occurring at concentrations as low as 0.1 µM in the mouse compared to 10 µM in Xenopus.6

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Technical Information
Formal Name
[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-acetic acid
CAS Number
50892-23-4
Synonyms
  • Pirinixic Acid
Molecular Formula
C14H14ClN3O2S
Formula Weight
323.8
Purity
≥98%
Formulation
A crystalline solid
λmax
244, 292 nm
SMILES
OC(=O)CSc1nc(cc(Cl)n1)Nc1cccc(C)c1C
InChI Code
InChI=1S/C14H14ClN3O2S/c1-8-4-3-5-10(9(8)2)16-12-6-11(15)17-14(18-12)21-7-13(19)20/h3-6H,7H2,1-2H3,(H,19,20)(H,16,17,18)
InChI Key
SZRPDCCEHVWOJX-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
Product Downloads

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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Devchand, P.R., Keller, H., Peters, J.M., et al. The PPARα-leukotriene B4 pathway to inflammation control Nature 384, 39-43 (1996).

2. Hsu, M.H., Palmer, C.N.A., Griffin, K.J., et al. A single amino acid change in the mouse peroxisome proliferator-activated receptor α alters transcriptional responses to peroxisome proliferators Molecular Pharmacology 48, 559-567 (1995).

3. Staels, B., Koenig, W., Habib, A., et al. Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators Nature 393, 790-793 (1998).

4. Lehmann, J.M., Lenhard, J.M., Oliver, B.B., et al. Peroxisome proliferator-activated receptors α and g are activated by indomethacin and other non-steroidal anti-inflammatory drugs The Journal of Biological Chemisty 272, 3406-3410 (1997).

5. Schmidt, A., Endo, N., Rutledge, S.J., et al. Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids Molecular Endocrinology 6, 1634-1641 (1992).

6. Keller, H., Devchand, P.R., Perroud, M., et al. PPARα structure-function relationships derived from species-specific differences in responsiveness to hypolipidemic agents Biological Chemistry 378, 651-655 (1997).

Product Citations

Kamarajugadda, S., Becker, J.R., Hanse, E.A., et al. Cyclin D1 represses peroxisome proliferator-activated receptor alpha and inhibits fatty acid oxidation Oncotarget 7(30), 47674-47686 (2016).

Change, Y.-C., Chen, Y.-J., Huang, C.-W., et al. Cyclic stretch facilitates myogenesis in C2C12 myoblasts and rescues thiazolidinedione-inhibited myotube formation Front. Bioeng. Biotechnol. 4(27), (2016).

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