An agonist of PPARα
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Wy 14643

Item No. 70730

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-acetic acid
CAS Number
50892-23-4
Synonyms
  • NSC 310038
  • Pirinixic Acid
Molecular Formula
C14H14ClN3O2S
Formula Weight
323.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 16.5 mg/mlPBS pH 7.2: 40 µg/ml
λmax
244, 292 nm
SMILES
OC(=O)CSc1nc(cc(Cl)n1)Nc1cccc(C)c1C
InChi Code
InChI=1S/C14H14ClN3O2S/c1-8-4-3-5-10(9(8)2)16-12-6-11(15)17-14(18-12)21-7-13(19)20/h3-6H,7H2,1-2H3,(H,19,20)(H,16,17,18)
InChi Key
SZRPDCCEHVWOJX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $18

    Add

    10 mg

    $24

    Add

    50 mg

    $69

    Add

    250 mg

    $212

    Add
    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    Wy 14643 is an agonist of peroxisome proliferator-activated receptor α (PPARα).1 It selectively transactivates PPARα over PPARγ in a reporter assay using CV-1 mouse fibroblasts when used at a concentration of 100 µM. Wy 14643 (2 mg/kg) decreases distal colon protein levels of IFN-γ, TNF-α, IL-1β, and IL-6 in a mouse model of experimental colitis induced by dextran sulfate sodium (DSS; Item No. 23250).2 Wy 14643 (0.1% w/w in the diet) reduces hepatic triglycerides, leukocyte recruitment, and fibrosis in a mouse model of methionine- and choline-deficient diet-induced steatohepatitis.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lehmann, J.M., Lenhard, J.M., Oliver, B.B., et al. Peroxisome proliferator-activated receptors α and γ are activated by indomethacin and other non-steroidal anti-inflammatory drugs. The Journal of Biological Chemisty 272(6), 3406-3410 (1997).

    2. Azuma, Y.-T., Nishiyama, K., Matsuo, Y., et al. PPARα contributes to colonic protection in mice with DSS-induced colitis. Int. Immunopharmacol. 10(10), 1261-1267 (2010).

    3. Ip, E., Farrell, G., Hall, P., et al. Administration of the potent PPARα agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice. Hepatology 39(5), (2004).

    Product Citations

    Das, S., Finney, A.C., Anand, S.K., et al. Inhibition of hepatic oxalate overproduction ameliorates metabolic dysfunction-associated steatohepatitis. Nat. Metab. 6(10), 1939-1962 (2024).

    Kamarajugadda, S., Becker, J.R., Hanse, E.A., et al. Cyclin D1 represses peroxisome proliferator-activated receptor alpha and inhibits fatty acid oxidation. Oncotarget 7(30), 47674-47686 (2016).

    Change, Y.-C., Chen, Y.-J., Huang, C.-W., et al. Cyclic stretch facilitates myogenesis in C2C12 myoblasts and rescues thiazolidinedione-inhibited myotube formation. Front. Bioeng. Biotechnol. 4(27), (2016).

    Hsu, W.-H., Chen, T.-H., Lee, B.-H., et al. Monascin and ankaflavin act as natural AMPK activators with PPARα agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice. Food Chem. Toxicol. 64, 94-103 (2014).

    Hsu, W.-H., Liao, T.-H., Lee, B.-H., et al. Ankaflavin regulates adipocyte function and attenuates hyperglycemia caused by high-fat diet via PPAR-γ activation. J. Funct. Foods 5(1), (2012).