We collect cookies for vital website function and to better serve our customers. By continuing to browse you agree to the storing of cookies on your device. See our privacy policy for details.


Item № 70790
CAS № 1675-54-3
Purity ≥85%
product image
                (CAS 1675-54-3)
     25 g $12.00 0.00
     50 g $22.00 0.00
     100 g $38.00 0.00
     500 g $120.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

  • Bisphenol A diglycidyl ether

PPARγ is a ligand-activated transcription factor involved in the regulation of lipid homeostasis and may function as a master regulator of adipogenesis.1,2,3,4 Ligands for PPARγ include antidiabetic drugs of the thiazolidinedione structural class, 15-deoxy-Δ12,14-prostaglandin J2, and NSAIDS.5,6,7,8 BADGE is a synthetic compound used in the production of polycarbonate and industrial plastics. This compound was recently identified as an antagonist of PPARγ.9 BADGE binds to PPARγ with an apparent Kd of 100 µM and interferes with the ability of 3T3-L1 and 3T3-F442A cells to undergo hormone-mediated cell differentiation.9

Recommended Products

Related Products
View Related Product Categories
View Screening Libraries with BADGE
Technical Information
Formal Name
CAS Number
  • Bisphenol A diglycidyl ether
Molecular Formula
Formula Weight
A neat oil
228, 277, 283 nm
InChI Code
InChI Key
  • Synthetic

Warning - this product is not for human or veterinary use.

Shipping & Storage
Room temperature
Ambient in continental US; may vary elsewhere
≥ 1 year
Downloads & Resources
Product Downloads

Download Product Insert

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Elbrecht, A., Chen, Y., Cullinan, C.A., et al. Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors γ 1 and γ 2 Biochemical and Biophysical Research Communications 224, 431-437 (1996).

2. Greene, M.E., Blumberg, B., McBride, O.W., et al. Isolation of the human peroxisome proliferator activated receptor γ cDNA: Expression in hematopoietic cells and chromosomal mapping Gene Expression 4, 281-299 (1995).

3. Spiegelman, B.M., and Flier, J.S. Adipogenesis and obesity: Rounding out the big picture Cell 87, 377-389 (1995).

4. Lemberger, T., Desvergne, B., and Wahli, W. Peroxisome proliferator-activated receptors: A nuclear receptor signaling pathway in lipid physiology Annual Reviews of Cell Development and Biology 12, 335-363 (1996).

5. Lehmann, J.M., Moore, L.B., Smith-Oliver, T.A., et al. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ) J. Biol. Chem. 270(22), 12953-12956 (1995).

6. Willson, T.M., Cobb, J.E., Cowan, D.J., et al. The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones J. Med. Chem. 39, 665-668 (1996).

7. Forman, B.M., Tontonoz, P., Chen, J., et al. 15-Deoxy-Δ12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ Cell 83(5), 803-812 (1995).

8. Lehmann, J.M., Lenhard, J.M., Oliver, B.B., et al. Peroxisome proliferator-activated receptors α and g are activated by indomethacin and other non-steroidal anti-inflammatory drugs The Journal of Biological Chemisty 272, 3406-3410 (1997).

9. Wright, H.M., Clish, C.B., Mikami, T., et al. A synthetic antagonist for the peroxisome proliferator-activated receptor γ inhibits adipocyte differentiation The Journal of Biological Chemisty 275, 1873-1877 (2000).

Technical Support

What is the density of BADGE?

The density of BADGE is 1.17 g/ml.

Contact Us
  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Cayman Contract Services

We work with scientists to accelerate their research, drug discovery, and drug development needs through our expertise in the following areas:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

Toll Free: (800) 364-9897

(USA and Canada Only)

Fax: (734) 971-3640