We collect cookies for vital website function and to better serve our customers. By continuing to browse you agree to the storing of cookies on your device. See our privacy policy for details.

MSDC-0160

Item № 71748
CAS № 146062-49-9
Purity ≥98%
product image
                (CAS 146062-49-9)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $39.00 0.00
     5 mg $137.00 0.00
     10 mg $234.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

Description

MSDC-0160 is a thiazolidinedione (TZD) with antidiabetic and neuroprotective activities.1 It inactivates the mitochondrial pyruvate carrier (MPC; IC50 = 1.2 mM) without affecting peroxisome proliferator-activated receptor γ (PPARγ; IC50 = 31.65 mM) in vitro.2 MSDC-0160 enhances the rate of insulin-stimulated lipogenesis in 3T3-L1 adipocytes in a dose-dependent manner.1 Dietary administration of MSDC-0160 (100 mg/kg) lowers blood glucose levels in obese, hyperglycemic, hyperinsulinemic, and insulin-resistant KKAγ mice. MSDC-0160 prevents neurodegeneration in a C. elegans model of Parkinson's disease, an effect that is blocked by knockdown of the mammalian target of rapamycin (mTOR).2 It also prevents overactivation of mTOR in the MPTP-induced and engrailed heterozygous (En+/-) mouse models of Parkinson's disease.

Recommended Products

Related Products
View Related Product Categories
Technical Information
Formal Name
5-[[4-[2-(5-ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione
CAS Number
146062-49-9
Molecular Formula
C19H18N2O4S
Formula Weight
370.4
Purity
≥98%
Formulation
A crystalline solid
λmax
231, 273 nm
SMILES
CCc1ccc(nc1)C(=O)COc1ccc(cc1)CC1SC(=O)NC1=O
InChI Code
InChI=1S/C19H18N2O4S/c1-2-12-5-8-15(20-10-12)16(22)11-25-14-6-3-13(4-7-14)9-17-18(23)21-19(24)26-17/h3-8,10,17H,2,9,11H2,1H3,(H,21,23,24)
InChI Key
IRNJSRAGRIZIHD-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
Product Downloads

Download Product Insert

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Tanis, S.P., Parker, T.T., Colca, J.R., et al. Synthesis and biological activity of metabolites of the antidiabetic, antihyperglycemic agent pioglitazone J. Med. Chem. 39(26), 5053-5063 (1996).

2. Quansah, E., Peelaerts, W., Langston, J.W., et al. Targeting energy metabolism via the mitochondrial pyruvate carrier as a novel approach to attenuate neurodegeneration Mol. Neurodegener. 13(1), 28 (2018).

Technical Support
Contact Us
  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Cayman Contract Services

We work with scientists to accelerate their research, drug discovery, and drug development needs through our expertise in the following areas:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

Toll Free: (800) 364-9897

(USA and Canada Only)

Fax: (734) 971-3640