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Curcumin

Item № 81025
CAS № 458-37-7
Purity ≥90%
product image
                (CAS 458-37-7)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 g $31.00 0.00
     10 g $47.00 0.00
     50 g $171.00 0.00
     100 g $310.00 0.00

Pricing updated 2019-06-19. Prices are subject to change without notice.

Description
Synonyms
  • Indian Saffron
  • Turmeric yellow

Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, and antitumor activities.1,2,3,4 It inhibits nitric oxide (NO) production (IC50 = 6 μM) and reduces inducible nitric oxide synthase (iNOS) activity in LPS-stimulated RAW 264.7 cells.1 Curcumin inhibits release of histamine and the inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 from HMC-1 mast cells.2 In vivo, curcumin decreases serum levels of histamine and TNF-α, inhibits histopathological changes of nasal mucosa, and decreases the number of sneezes and nasal rubbing in a mouse model of ovalbumin-induced rhinitis. Curcumin (100 or 200 mg/kg) prevents ovalbumin-induced accumulation of 3-nitrotyrosine (3-NT), a marker of oxidative stress, in mouse heart. Topical administration of curcumin (1-10 μmol) reduces the number of tumors induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mouse skin.3 Dietary administration of curcumin reduces the number of tongue neoplasms and preneoplastic lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in rats.4

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Technical Information
Formal Name
1,7-bis(4-hydroxy-3-methoxyphenyl)-1E,6E-heptadiene-3,5-dione
CAS Number
458-37-7
Synonyms
  • Indian Saffron
  • Turmeric yellow
Molecular Formula
C21H20O6
Formula Weight
368.4
Purity
≥90%
Formulation
A crystalline solid
λmax
427 nm
SMILES
COc1cc(/C=C\C(=O)CC(=O)\C=C/c2ccc(O)c(OC)c2)ccc1O
InChI Code
InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+
InChI Key
VFLDPWHFBUODDF-FCXRPNKRSA-N
Origin
  • Plant/Turmeric

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

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References & Product Citations
Product Description References

1. Brouet, I., and Ohshima, H. Curcumin, an anti-tumor promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages Biochemical and Biophysical Research Communications 206, 533-540 (1995).

2. Zhang, N., Li, H., Jia, J., et al. Anti-inflammatory effect of curcumin on mast cell-mediated allergic responses in ovalbumin-induced allergic rhinitis mouse Cell. Immunol. 298(1-2), 88-95 (2015).

3. Conney, A.H., Lysz, T., Ferraro, T., et al. Inhibitory effect of curcumin and some related dietary compounds on tumor promotion and arachidonic acid metabolism in mouse skin Advances in Enzyme Regulation 31, 385-396 (1991).

4. Tanaka, T., Makita, H., Ohnishi, M., et al. Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by dietary curcumin and hesperidin: Comparison with the protective effect of β-carotene Cancer Research 54, 4653-4659 (1994).

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