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N-Arachidonoyl Dopamine

Item № 90057
CAS № 199875-69-9
Purity ≥98%
product image
                (CAS 199875-69-9)
     5 mg $42.00 0.00
     10 mg $80.00 0.00
     50 mg $336.00 0.00
     100 mg $529.00 0.00

Pricing updated 2019-07-21. Prices are subject to change without notice.

  • NADA

Several different arachidonoyl amino acids, including N-arachidonoyl dopamine (NADA), have been isolated and characterized from bovine brain.1 NADA is the amide of the neurotransmitter dopamine and arachidonic acid. NADA is a CB1-selective agonist, inducing the typical tetrad of hypothermia, analgesia, catalepsy, and hypomotility in rats which exceeds that of anandamide (AEA).2 NADA is a full agonist at the vanilloid receptor 1, but is inactive on the dopaminergic D1 and D2 receptors. NADA is also a potent inhibitor (IC50 = 0.25 µM) of the proliferation of MCF-7 breast carcinoma cells. Recent reports of NADA’s endothelium-dependent vasodilation indicate that some of its cannabinergic activities antagonized by SR141716A may be non-CB1/CB2 dependent.3

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Technical Information
Formal Name
CAS Number
  • NADA
Molecular Formula
Formula Weight
A solution in ethanol
211, 284 nm
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Wet ice in continental US; may vary elsewhere
≥ 1 year
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References & Product Citations
Product Description References

1. Huang, S.M., Bisogno, T., Petros, T.J., et al. Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain The Journal of Biological Chemisty 276(46), 42639-42644 (2001).

2. Bisogno, T., Melck, D., Bobrov, M.Y., et al. N-acyl-dopamines: Novel synthetic CB1 cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo Biochemistry Journal 351, 817-824 (2001).

3. Randall, M., and Maxey, K.M. Personal Communication (2003).

Product Citations

Kantae, V., Ogino, S., Noga, M., et al. Quantitative profiling of endocannabinoids and related N-acylethanolamines in human CSF using nano LC-MS/MS J. Lipid. Res. 58(3), 615-624 (2017).

Matsumoto, G., Inobe, T., Amano, T., et al. N-Acyldopamine induces aggresome formation without proteasome inhibition and enhances protein aggregation via p62/SQSTM1 expression Sci. Rep. 8(1), 9585 (2018).

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