Formulation: A solution in methanol
Pricing updated 2019-03-21. Prices are subject to change without notice.
Cannabidiol is an active phytocannabinoid identified in Cannabis (composes ~40% of the plant's extract). Unlike Δ9-THC (Item No. 12068), cannabidiol is considered to be non-psychoactive.1 Cannabidiol has a very low affinity for CB1 and CB2 receptors but acts as an indirect antagonist and is thought to potentiate the effects of Δ9-THC.2 Cannabidiol is reported to act as an CB2 receptor inverse agonist, GPR55 antagonist, and a 5-HT1A receptor agonist.2,3,4,5 It can allosterically modulate μ and δ-opioid receptors as well as agonize PPARγ receptors and stimulate intracellular calcium release.6,7
Warning - this product is not for human or veterinary use.
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Kozela, E., Juknat, A., Kaushansky, N., et al. Cannabidiol, a non-
Mechoulam, R., Peters, M., Murillo-
Pertwee, R.G. The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-
4. Ryberg, E., Larsson, N., Sjögren, S., et al. The orphan receptor GPR55 is a novel cannabinoid receptor British Journal of Pharmacology 152, 1092-1101 (2007).
Russo, E.B., Burnett, A., Hall, B., et al. Agonistic properties of cannabidiol at 5-
Campos, A.C., Moreira, F.A., Gomes, F.V., et al. Multiple mechanisms involved in the large-
Kathmann, M., Flau, K., Redmer, A., et al. Cannabidiol is an allosteric modulator at mu-
Thapa, D., Cairns, E.A., Szczesniak, A.-