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Oleic Acid

Item № 90260
CAS № 112-80-1
Purity ≥98%
product image
                (CAS 112-80-1)
     500 mg $16.00 0.00
     1 g $21.00 0.00
     5 g $64.00 0.00
     10 g $80.00 0.00

Pricing updated 2019-04-25. Prices are subject to change without notice.

  • ​cis-9-Octadecenoic acid

Oleic acid is a monounsaturated fatty acid and a major component of membrane phospholipids that has been found in human plasma, cell membranes, and adipose tissue.1,2 It contributes approximately 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets.1 Oleic acid inhibits collagen-stimulated platelet aggregation by approximately 90% when used at a concentration of 10 µg/ml. It also inhibits fMLF-induced neutrophil aggregation and degranulation by 55 and 68%, respectively, when used at a concentration of 5 µM, similar to arachidonic acid (Item No. 90010).3 Oleic acid (60 µM) induces release of intracellular calcium in human platelets.4 In vivo, oleic acid increases TNF-α, IL-8, IL-6, and IL-1β production, neutrophil accumulation, and apoptotic and necrotic cell death in mouse lung and has been used to induce lung injury in a mouse model of acute respiratory distress syndrome (ARDS).2

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Technical Information
Formal Name
9Z-Octadecenoic acid
CAS Number
  • ​cis-9-Octadecenoic acid
Molecular Formula
Formula Weight
A solution in ethanol
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Wet ice in continental US; may vary elsewhere
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Wahle, K.W., and Peacock, L.I. Effects of isomeric cis and trans eighteen carbon monounsaturated fatty acids on porcine platelet function Biochim Biophys. Acta. 1301(1-2), 141-149 (1996).

2. Gonçalves-de-Albuquerque, C.F., Silva, A.R., Burth, P., et al. Acute respiratory distress syndrome: Role of oleic acid-triggered lung injury and inflammation Mediators Inflamm. 260465, (2015).

3. Naccache, P.H., Moiski, T.F., Volpi, M., et al. Modulation of rabbit neutrophil aggregation and degranulation by free fatty acids J. Leukoc. Biol. 36(3), 333-340 (1984).

4. Siafaka-Kapadai, A., Hanahan, D.J., and Javors, M.A. Oleic acid-induced Ca2+ mobilization in human platelets: Is oleic acid an intracellular messenger? J. Lipid Mediat. Cell Signal 15(3), 215-232 (1997).

Product Citations

Magtanong, L., Ko, P.-J., To, M., et al. Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state Cell Chem. Biol. 26, 1-13 (2019).

Mildenberger, J., Johansson, I., Sergin, I., et al. N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2 Autophagy 13(10), 1664-1678 (2017).

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