A natural metabolite of LTB4
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12-oxo Leukotriene B4

Item No. 20140

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5S-hydroxy-12-oxo-6Z,8E,10E,14Z-eicosatetraenoic acid
CAS Number
136696-10-1
Synonyms
  • 12-keto LTB4
  • 12-oxo LTB4
Molecular Formula
C20H30O4
Formula Weight
334.4
Purity
≥90%
Formulation (Request formulation change)
A 100 µg/ml solution in acetonitrile
Solubility(Learn about Variance in Solubility)
DMF: MiscibleDMSO: MiscibleEthanol: MisciblePBS (pH 7.2): > 1 mg/ml
λmax
314 nm
SMILES
CCCCC/C=C\CC(=O)\C=C/C=C\C=C\[C@@H](O)CCCC(=O)O
InChi Code
InChI=1S/C20H30O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,19,22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t19-/m1/s1
InChi Key
SJVWVCVZWMJXOK-NOJHDUNKSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    Product Description

    12-oxo LTB4 is an initial metabolite of LTB4 formed via the LTB4 12-hydroxydehydrogenase pathway.1,2,3 It is rapidly converted to 10,11-dihydro-12-oxo-LTB4, followed by reduction of the 12-oxo group to give 10,11-dihydro-LTB4.2 12-oxo-LTB4 (EC50 = 33 nM) is about 70-fold less potent than LTB4 (EC50 = 0.46 nM) at stimulating Ca2+ mobilization in human neutrophils.4 It is also significantly less potent than LTB4 at stimulating neutrophil migration with EC50 values of 170 and 2.7 nM for 12-oxo-LTB4 and LTB4, respectively.4

    WARNING This product is not for human or veterinary use.