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Lipoxin B4

Item No. 90420

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
98049-69-5
Synonyms
  • LXB4
Formula Weight
352.5
Solubility(Learn about Variance in Solubility)
DMF: >50 mg/mlEthanol: >50 mg/mlPBS pH 7.2: >1 mg/ml (from 13(S)-HODE)
SMILES
O[C@@H](CCCC(O)=O)/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](O)CCCCC
InChi Code
InChI=1S/C20H32O5/c1-2-3-8-14-18(22)19(23)15-10-7-5-4-6-9-12-17(21)13-11-16-20(24)25/h4-7,9-10,12,15,17-19,21-23H,2-3,8,11,13-14,16H2,1H3,(H,24,25)/b6-4-,7-5+,12-9+,15-10+/t17-,18+,19-/m1/s1
InChi Key
UXVRTOKOJOMENI-WLPVFMORSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 µg

    $302

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    50 µg

    $571

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    100 µg

    $1,078

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    Product Description

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Citations

    Wu, Z., Xiao, H., Rao, D., et al. Analytical strategy for oxylipin annotation by combining chemical derivatization-based retention index algorithm and feature tandem mass spectrometric fragmentation as a biomarker discovery tool. Anal. Chem. 95(43), 15933-15942 (2023).

    Roberts, L.M., Schwarz, B., Speranza, E., et al. Pulmonary infection induces persistent, pathogen-specific lipidomic changes influencing trained immunity. iScience 24(9), 103025 (2021).

    Hartling, I., Cremonesi, A., Osuna, E., et al. Quantitative profiling of inflammatory and pro-resolving lipid mediators in human adolescents and mouse plasma using UHPLC-MS/MS. Clin. Chem. Lab. Med. 59(11), 1811-1823 (2021).

    Liu, F., Zuo, X., Liu, Y., et al. Suppression of membranous LRP5 recyling, Wnt/β-catenin signaling, and colon carcinogenesis by 15-LOX-1 peroxidation of linoleic acid in PI3P. Cell Rep. 32(7), 108049 (2020).

    Brouwers, H., Jónasdóttir, H.S., Kuipers, M.E., et al. Anti-inflammatory and proresolving effects of the omega-6 polyunsaturated fatty acid adrenic acid. J. Immunol. 205(10), 2840-2849 (2020).

    Meriwether, D., Sulaiman, D., Volpe, C., et al. Apolipoprotein A-I mimetics mitigate intestinal inflammation in COX2-dependent inflammatory bowel disease model. J. Clin. Invest. 130, 3670-3685 (2019).

    Dakin, S.G., Colas, R.A., Wheway, K., et al. Proresolving mediators LXB4 and RevE1 regulate inflammation in stromal cells from patients with shoulder tendon tears. Am. J. Pathol. 189(11), 2258-2268 (2019).

    Kutzner, L., Rund, K.M., Ostermann, A.I., et al. Development of an optimized LC-MS method for the detection of specialized pro-resolving mediators in biological samples. Front. Pharmacol. 10, 169 (2019).

    Kim, N., Lannan, K.L., Thatcher, T.H., et al. Lipoxin B4 enhances human memory B cell antibody production via upregulating cyclooxygenase-2 expression. J. Immunol. 201(11), 3343-3351 (2018).

    Dalli, J., Colas, R.A., Walker, M.E., et al. Lipid Mediator Metabolomics via LC-MS/MS Profiling and Analysis. Clinical Metabolomics 59-72 (2018).

    Sasaki, A., Fukuda, H., Shiida, N., et al. Determination of ω-6 and ω-3 PUFA metabolites in human urine samples using UPLC/MS/MS. Anal. Bioanal. Chem. 407(6), 1625-1639 (2015).