An HDAC inhibitor
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CAY10398

Item No. 89740

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide
CAS Number
193551-00-7
Synonyms
  • MD 85
  • PX 089274
Molecular Formula
C15H23N3O3
Formula Weight
293.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:5): 300 µg/mlDMSO: 14 mg/mlEthanol: 1 mg/ml
λmax
301 nm
SMILES
ONC(=O)CCCCCNC(=O)c1ccc(cc1)N(C)C
InChi Code
InChI=1S/C15H23N3O3/c1-18(2)13-9-7-12(8-10-13)15(20)16-11-5-3-4-6-14(19)17-21/h7-10,21H,3-6,11H2,1-2H3,(H,16,20)(H,17,19)
InChi Key
RGWSSTALGUXZMU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $24

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    5 mg

    $98

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    10 mg

    $173

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    25 mg

    $376

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    Cayman Chemical
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    Product Description

    CAY10398 is a histone deacetylase (HDAC) inhibitor (IC50 = 0.244 µM in H1299 cell lysates).1 It inhibits HDAC1, HDAC3, and HDAC6 (IC50s = 0.39, 0.39, and 0.33 µM, respectively) and inhibits the proliferation of K562 leukemia cells (IC50 = 2.2 µM).2 CAY10398 is also active against drug-sensitive and -resistant strains of P. falciparum (IC50s = 0.2723-0.726 µM).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Remiszewski, S.W., Sambucetti, L.C., Atadja, P., et al. Inhibitors of human histone deacetylase: Synthesis and enzyme and cellular activity of straight chain hydroxamates. J. Med. Chem. 45(4), 753-757 (2002).

    2. Wittich, S., Scherf, H., Xie, C., et al. Effect of inhibitors of histone deacetylase on the induction of cell differentiation in murine and human erythroleukemia cell lines. Anticancer Drugs 16(6), 635-643 (2005).

    3. Coetzee, N., von Grüning, H., Opperman, D., et al. Epigenetic inhibitors target multiple stages of Plasmodium falciparum parasites. Sci. Rep. 10(1), (2020).